PDF(Pubmed)
Abstract：
Congenital abnormalities in the development of the thyroglossal duct are a common pathology in the pediatric population. The exact frequency of hemiagenesis of the thyroid gland is not known because the condition is rarely manifested clinically and is almost always discovered incidentally. Papillary carcinoma of thyroglossal cysts is relatively uncommon, has a good prognosis if promptly detected and treated and occurs mainly in adults. The case we present here is an extremely rare occurrence: a patient with papillary thyroid carcinoma of the thyroglossal duct cyst and thyroglossal duct cyst carcinoma (TDCa). So far, only two such adult patients (women aged 24 and 35) have been described in the world medical literature. The patient we present is a 14-year-old female and is the first described adolescent with papillary carcinoma of the thyroglossal duct cyst and thyroid hemiagenesis (THA). The disease didn\'t have any clinical manifestations, and the patient was brought in by her parents to improve her aesthetic appearance. Neither the physical examination nor the radiological evaluation showed any signs of malignancy. The diagnosis was reached by our team only after the patoanatomical examination. In this patient\'s case, due to its early diagnosis, the spread of the disease was limited only to the borders of the thyroglossal duct cyst and the absence of regional and distant metastasis. Surgical removal led to a complete cure, without any postoperative data suggestive of residual disease. The functions of the thyroid gland in her case were not affected, despite her left-lobe agenesis, to which there are multiple proofs, namely the normal blood concentration of the examined thyroid markers: free triiodothyronine (FT3), free thyroxine (FT4), thyroglobulin (TG), thyroid stimulating hormone (TSH), anti-TG (thyroid antibody test (TAT)), anti-thyroid peroxidase (TPO) (microsomal antibody test (MAT)), and normal physical and psychological development.
摘要：
甲状舌管发育的先天性异常是儿科人群中的常见病理。甲状腺造血的确切频率尚不清楚，因为这种情况很少在临床上表现出来，几乎总是偶然发现。甲状腺舌管囊肿的乳头状癌相对少见，如果及时发现和治疗，预后良好，主要发生在成人。我们在这里提出的病例极为罕见：患有甲状腺舌管囊肿和甲状腺舌管囊肿癌（TDCa）的甲状腺乳头状癌。到目前为止,世界医学文献中只描述了两名这样的成年患者(24岁和35岁的女性)。我们介绍的患者是一名14岁的女性，是第一个被描述为患有甲状舌管囊肿和甲状腺发育不全（THA）的乳头状癌的青少年。这种疾病没有任何临床表现,病人是由她的父母带来的，以改善她的美学外观。体格检查和放射学评估均未显示任何恶性肿瘤迹象。只有在进行了局部解剖检查后，我们的团队才做出了诊断。在这个病人的情况下，由于其早期诊断，该疾病的传播仅限于甲状舌管囊肿的边界，并且没有区域和远处转移。手术切除导致完全治愈，没有任何术后数据提示残留疾病。在她的病例中，甲状腺的功能没有受到影响，尽管她左叶发育不全,有多个证据，即所检查的甲状腺标志物的正常血液浓度：游离三碘甲状腺原氨酸（FT3），游离甲状腺素（FT4），甲状腺球蛋白(TG),促甲状腺激素(TSH),抗TG（甲状腺抗体测试（TAT）），抗甲状腺过氧化物酶（TPO）（微粒体抗体测试（MAT）），和正常的身体和心理发展。
