PDF(Pubmed)
Abstract：
Castleman disease (CD) is a rare lymphoproliferative disorder characterized by localized (unicentric) or systemic (multicentric) lymphadenopathy. This study presents a unique case of a 29-year-old female with a rare pelvic presentation of unicentric Castleman disease, specifically the hyaline vascular variant. Despite surgical resection, an unresectable residual lesion prompted adjuvant radiotherapy and subsequent chemotherapy. The literature highlights surgical resection as the primary treatment for localized Castleman disease; however, radiotherapy and combined chemotherapy regimens like cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) have shown promise in unresectable cases, emphasizing a multidisciplinary approach. This case underscores the importance of tailoring treatment strategies for uncommon Castleman disease presentations.
摘要：
Castleman病（CD）是一种罕见的淋巴增生性疾病，其特征是局部（单中心）或全身（多中心）淋巴结病。这项研究提出了一个独特的病例，一名29岁的女性患有罕见的单中心Castleman病的骨盆表现，特别是透明血管变体。尽管手术切除,不可切除的残留病变提示辅助放疗和随后的化疗。文献强调手术切除是局部Castleman病的主要治疗方法；然而，放疗和环磷酰胺等联合化疗方案，阿霉素,长春新碱,和泼尼松（CHOP）在不可切除的病例中显示出希望，强调多学科方法。此病例强调了为罕见的Castleman疾病表现定制治疗策略的重要性。
