PDF(Pubmed)
Abstract：
Introduction: Motilin (MLN) is a gastrointestinal (GI) hormone produced in the upper small intestine. Its most well understood function is to participate in Phase III of the migrating myoelectric complex component of GI motility. Changes in MLN availability are associated with GI diseases such as gastroesophageal reflux disease and functional dyspepsia. Furthermore, herbal medicines have been used for several years to treat various GI disorders. We systematically reviewed clinical and animal studies on how herbal medicine affects the modulation of MLN and subsequently brings the therapeutic effects mainly focused on GI function. Methods: We searched the PubMed, Embase, Cochrane, and Web of Science databases to collect all articles published until 30 July 2023, that reported the measurement of plasma MLN levels in human randomized controlled trials and in vivo herbal medicine studies. The collected characteristics of the articles included the name and ingredients of the herbal medicine, physiological and symptomatic changes after administering the herbal medicine, changes in plasma MLN levels, key findings, and mechanisms of action. The frequency patterns (FPs) of botanical drug use and their correlations were investigated using an FP growth algorithm. Results: Nine clinical studies with 1,308 participants and 20 animal studies were included in the final analyses. Herbal medicines in clinical studies have shown therapeutic effects in association with increased levels of MLN, including GI motility regulation and symptom improvement. Herbal medicines have also shown anti-stress, anti-tumor, and anti-inflammatory effects in vivo. Various biochemical markers may correlate with MLN levels. Markers may have a positive correlation with plasma MLN levels included ghrelin, acetylcholine, and secretin, whereas a negative correlation included triglycerides and prostaglandin E2. Markers, such as gastrin and somatostatin, did not show any correlation with plasma MLN levels. Based on the FP growth algorithm, Glycyrrhiza uralensis and Paeonia japonica were the most frequently used species. Conclusion: Herbal medicine may have therapeutic effects mainly on GI symptoms with involvement of MLN regulation and may be considered as an alternative option for the treatment of GI diseases. Further studies with more solid evidence are needed to confirm the efficacy and mechanisms of action of herbal medicines. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=443244, identifier CRD42023443244.
摘要：
简介：胃动素（MLN）是一种在小肠上部产生的胃肠（GI）激素。其最广为人知的功能是参与GI运动的迁移肌电复杂成分的III期。MLN可用性的变化与胃肠道疾病如胃食管反流病和功能性消化不良相关。此外，多年来，草药已被用于治疗各种胃肠道疾病。我们系统地回顾了关于草药如何影响MLN调节的临床和动物研究，并随后带来了主要集中在GI功能上的治疗效果。方法：我们搜索了PubMed，Embase,科克伦,和WebofScience数据库收集直到2023年7月30日发表的所有文章，这些文章报道了人体随机对照试验和体内草药研究中血浆MLN水平的测量。收集的文章特征包括草药的名称和成分，服用草药后的生理和症状变化，血浆MLN水平的变化，关键发现,和行动机制。使用FP生长算法研究了植物药使用的频率模式（FP）及其相关性。结果：最终分析中包括9项临床研究，1,308名参与者和20项动物研究。临床研究中的草药已显示出与MLN水平升高相关的治疗效果，包括胃肠动力调节和症状改善。草药也显示出抗压力，抗肿瘤，和体内抗炎作用。各种生化标志物可与MLN水平相关。标志物可能与血浆MLN水平呈正相关，包括ghrelin，乙酰胆碱，和促胰液素,而负相关包括甘油三酯和前列腺素E2。标记,如胃泌素和生长抑素，与血浆MLN水平无相关性。基于FP增长算法，甘草和牡丹是最常用的物种。结论：中药可能主要对胃肠道症状具有治疗作用，并参与MLN调节，可作为胃肠道疾病的替代选择。需要更多确凿证据的进一步研究来证实草药的功效和作用机制。系统审查注册：https://www。crd.约克。AC.uk/prospro/display_record.php?RecordID=443244，标识符CRD42023443244。
