PDF(Pubmed)
Abstract：
UNASSIGNED: Decreasing white matter integrity in limbic pathways including the fornix and cingulum have been reported in Alzheimer\'s disease (AD), although underlying mechanisms and potential sex differences remain understudied. We therefore sought to explore sex as a moderator of the effect of age on myelin water fraction (MWF), a measure of myelin content, in older adults without dementia (N = 52).
UNASSIGNED: Participants underwent neuropsychological evaluation and 3 T MRI at two research sites. Multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) quantified MWF in 3 a priori regions including the fornix, hippocampal cingulum (CgH), and cingulate cingulum (CgC). The California Verbal Learning Test-Second Edition assessed learning and delayed recall. Multiple linear regressions assessed for (1) interactions between age and sex on regional MWF and (2) associations of regional MWF and memory.
UNASSIGNED: (1) There was a significant age by sex interaction on MWF of the fornix (p = 0.002) and CgC (p = 0.005), but not the CgH (p = 0.192); as age increased, MWF decreased in women but not men. (2) Fornix MWF was associated with both learning and recall (ps < 0.01), but MWF of the two cingulum regions were not (p > 0.05). Results were unchanged when adjusting for hippocampal volume.
UNASSIGNED: The current work adds to the literature by illuminating sex differences in age-related myelin decline using a measure sensitive to myelin and may help facilitate detection of AD risk for women.
UNASSIGNED: Participants underwent neuropsychological evaluation and 3 T MRI at two research sites. Multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) quantified MWF in 3 a priori regions including the fornix, hippocampal cingulum (CgH), and cingulate cingulum (CgC). The California Verbal Learning Test-Second Edition assessed learning and delayed recall. Multiple linear regressions assessed for (1) interactions between age and sex on regional MWF and (2) associations of regional MWF and memory.
UNASSIGNED: (1) There was a significant age by sex interaction on MWF of the fornix (p = 0.002) and CgC (p = 0.005), but not the CgH (p = 0.192); as age increased, MWF decreased in women but not men. (2) Fornix MWF was associated with both learning and recall (ps < 0.01), but MWF of the two cingulum regions were not (p > 0.05). Results were unchanged when adjusting for hippocampal volume.
UNASSIGNED: The current work adds to the literature by illuminating sex differences in age-related myelin decline using a measure sensitive to myelin and may help facilitate detection of AD risk for women.
摘要：
■在阿尔茨海默病（AD）中，已经报道了包括穹窿和扣带在内的边缘途径中白质完整性的降低，尽管潜在的机制和潜在的性别差异仍未得到充分研究。因此，我们试图探索性别作为年龄对髓磷脂水分数（MWF）影响的调节因素，衡量髓鞘含量，没有痴呆的老年人（N=52）。
■参与者在两个研究地点接受了神经心理学评估和3TMRI。多组分驱动平衡单脉冲观察T1和T2(mcDESPOT)量化MWF在3个先验区域包括穹窿，海马扣带（CgH），扣带（CgC）。加州言语学习测试-第二版评估学习和延迟召回。多元线性回归评估（1）年龄和性别对区域MWF的相互作用，以及（2）区域MWF和记忆的关联。
■（1）穹窿的MWF（p=0.002）和CgC（p=0.005）存在性别相互作用的显着年龄，但不是CgH(p=0.192)；随着年龄的增长，女性的MWF下降，但男性没有下降。(2)FornixMWF与学习和回忆有关(ps<0.01)。但两个扣带区的MWF均无差异(p>0.05)。当调整海马体积时，结果没有变化。
■当前的工作通过使用对髓磷脂敏感的措施阐明年龄相关的髓磷脂下降的性别差异来增加文献，并可能有助于促进女性AD风险的检测。
■参与者在两个研究地点接受了神经心理学评估和3TMRI。多组分驱动平衡单脉冲观察T1和T2(mcDESPOT)量化MWF在3个先验区域包括穹窿，海马扣带（CgH），扣带（CgC）。加州言语学习测试-第二版评估学习和延迟召回。多元线性回归评估（1）年龄和性别对区域MWF的相互作用，以及（2）区域MWF和记忆的关联。
■（1）穹窿的MWF（p=0.002）和CgC（p=0.005）存在性别相互作用的显着年龄，但不是CgH(p=0.192)；随着年龄的增长，女性的MWF下降，但男性没有下降。(2)FornixMWF与学习和回忆有关(ps<0.01)。但两个扣带区的MWF均无差异(p>0.05)。当调整海马体积时，结果没有变化。
■当前的工作通过使用对髓磷脂敏感的措施阐明年龄相关的髓磷脂下降的性别差异来增加文献，并可能有助于促进女性AD风险的检测。
