PDF(Pubmed)
Abstract：
UNASSIGNED: Circumscribed or pseudomalignant myositis ossificans (MO) is a rare and benign condition characterized by heterotopic bone formation in soft tissues. The clinical presentation of MO, imaging investigations, histological findings, and treatment strategies are unclear, especially in the pediatric population.
UNASSIGNED: A literature search was conducted in PubMed, Scopus, and Google Scholar electronic databases to identify original articles and reviews in English or French of traumatic and non-traumatic MO. Studies were selected by 2 independent reviewers following the PRISMA recommendation and descriptive data were extracted. We harvest in each case the sex, age at diagnosis, location, presence of initial trauma, pre-emptive diagnosis, modalities of imagery used, realized biopsy, treatment performed, and type of follow-up.
UNASSIGNED: Sixty pediatric cases of MO were identified between 2002 and 2023. Twenty-three patients (38.3%) were diagnosed with idiopathic/pseudomalignant and 37 patients (61.7%) with circumscribed. The mean age at diagnosis was 9.5 years (range 0.2-17 years), with a male-to-female ratio of 1:1. The initial pre-emptive diagnosis was neoplasia in 13 patients (21.7%). The biopsy was percutaneous in 9 patients (15%) and incisional in 7 patients (11.7%). Histological analysis was achieved in 35 cases (57%). Surgical excision was the first line treatment in 46.7% of patients, and non-surgical in the remaining patients. The follow-up strategy was clinical in 16 patients (26.7%) or based on imaging investigation in 23 patients (38.3%).
UNASSIGNED: Although MO in children is described as a rare pathology, identifying the benignity of the condition is essential to avoid unnecessary invasive treatment and to avoid delaying the treatment of a potentially life-threatening entity. It seems that there is no consensus established concerning the proper imaging for diagnosis. Clinicians should acknowledge that the absence of a triggering trauma tends to direct the investigation and the management toward a surgical attitude. Conservative management is key, however, surgical excision can be proposed on matured lesions on a case-by-case basis. The absence of recurrence is not excluded. Therefore, a close clinical follow-up is suggested for all cases. The true benefit of a radiological is questioned in a question known to be self-resolving.
UNASSIGNED: A literature search was conducted in PubMed, Scopus, and Google Scholar electronic databases to identify original articles and reviews in English or French of traumatic and non-traumatic MO. Studies were selected by 2 independent reviewers following the PRISMA recommendation and descriptive data were extracted. We harvest in each case the sex, age at diagnosis, location, presence of initial trauma, pre-emptive diagnosis, modalities of imagery used, realized biopsy, treatment performed, and type of follow-up.
UNASSIGNED: Sixty pediatric cases of MO were identified between 2002 and 2023. Twenty-three patients (38.3%) were diagnosed with idiopathic/pseudomalignant and 37 patients (61.7%) with circumscribed. The mean age at diagnosis was 9.5 years (range 0.2-17 years), with a male-to-female ratio of 1:1. The initial pre-emptive diagnosis was neoplasia in 13 patients (21.7%). The biopsy was percutaneous in 9 patients (15%) and incisional in 7 patients (11.7%). Histological analysis was achieved in 35 cases (57%). Surgical excision was the first line treatment in 46.7% of patients, and non-surgical in the remaining patients. The follow-up strategy was clinical in 16 patients (26.7%) or based on imaging investigation in 23 patients (38.3%).
UNASSIGNED: Although MO in children is described as a rare pathology, identifying the benignity of the condition is essential to avoid unnecessary invasive treatment and to avoid delaying the treatment of a potentially life-threatening entity. It seems that there is no consensus established concerning the proper imaging for diagnosis. Clinicians should acknowledge that the absence of a triggering trauma tends to direct the investigation and the management toward a surgical attitude. Conservative management is key, however, surgical excision can be proposed on matured lesions on a case-by-case basis. The absence of recurrence is not excluded. Therefore, a close clinical follow-up is suggested for all cases. The true benefit of a radiological is questioned in a question known to be self-resolving.
摘要：
■封闭式或假性恶性骨化性肌炎（MO）是一种罕见且良性的疾病，其特征是在软组织中形成异位骨。MO的临床表现，影像调查，组织学发现，治疗策略还不清楚，尤其是在儿科人群中。
■在PubMed进行了文献检索，Scopus,和GoogleScholar电子数据库，以识别英语或法语的创伤性和非创伤性MO的原始文章和评论。根据PRISMA建议，由2名独立评审员选择研究，并提取描述性数据。我们在每种情况下都收获了性别，诊断时的年龄，location,初始创伤的存在，先发制人的诊断,使用的图像模式，实现活检，进行治疗，和后续行动的类型。
■在2002年至2023年之间发现了60例小儿MO。23例（38.3％）被诊断为特发性/假性恶性，37例（61.7％）被诊断为局限性。诊断时的平均年龄为9.5岁（范围为0.2-17岁），男女比例为1:1。最初的先发制人诊断为13例患者（21.7％）。9例（15％）经皮活检，7例（11.7％）切开活检。35例（57％）实现了组织学分析。手术切除是46.7%患者的一线治疗,其余患者非手术。随访策略为16例患者（26.7％）或基于23例患者（38.3％）的影像学检查。
■尽管儿童中的MO被描述为一种罕见的病理，确定病情的良性对于避免不必要的侵入性治疗和避免延迟治疗可能危及生命的实体至关重要.似乎没有关于诊断的正确成像的共识。临床医生应该承认，没有触发性创伤倾向于将调查和管理引向手术态度。保守管理是关键,然而,可以根据具体情况对成熟的病变进行手术切除。不排除复发。因此,建议对所有病例进行密切的临床随访。在一个已知为自我解决的问题中，放射学的真正益处受到质疑。
■在PubMed进行了文献检索，Scopus,和GoogleScholar电子数据库，以识别英语或法语的创伤性和非创伤性MO的原始文章和评论。根据PRISMA建议，由2名独立评审员选择研究，并提取描述性数据。我们在每种情况下都收获了性别，诊断时的年龄，location,初始创伤的存在，先发制人的诊断,使用的图像模式，实现活检，进行治疗，和后续行动的类型。
■在2002年至2023年之间发现了60例小儿MO。23例（38.3％）被诊断为特发性/假性恶性，37例（61.7％）被诊断为局限性。诊断时的平均年龄为9.5岁（范围为0.2-17岁），男女比例为1:1。最初的先发制人诊断为13例患者（21.7％）。9例（15％）经皮活检，7例（11.7％）切开活检。35例（57％）实现了组织学分析。手术切除是46.7%患者的一线治疗,其余患者非手术。随访策略为16例患者（26.7％）或基于23例患者（38.3％）的影像学检查。
■尽管儿童中的MO被描述为一种罕见的病理，确定病情的良性对于避免不必要的侵入性治疗和避免延迟治疗可能危及生命的实体至关重要.似乎没有关于诊断的正确成像的共识。临床医生应该承认，没有触发性创伤倾向于将调查和管理引向手术态度。保守管理是关键,然而,可以根据具体情况对成熟的病变进行手术切除。不排除复发。因此,建议对所有病例进行密切的临床随访。在一个已知为自我解决的问题中，放射学的真正益处受到质疑。
