Abstract：
Trimethylamine-N-oxide (TMAO) is a common intestinal metabolite. The Choline in the nutrient forms TMA under the action of the gut microbiota, which passes through the liver and eventually forms TMAO. Initial studies of TMAO focused on cardiovascular disease, but as research progressed, TAMO\'s effects were found to be multisystem and closely related to the development of neurological diseases. Intestinal tract is the organ with the largest concentration of bacteria in human body, and the composition and metabolism of gut microbiota affect human health. As a two-way communication axis connecting the central nervous system and the gastrointestinal tract, the brain-gut axis provides the structural basis for TMAO to play its role. This article will review the correlation between TMA/TMAO and neurological diseases in order to find new directions and new targets for the treatment of neurological diseases.
摘要：
三甲胺-N-氧化物(TMAO)是一种常见的肠代谢产物。营养素中的胆碱在肠道微生物群的作用下形成TMA，它通过肝脏并最终形成TMAO。TMAO的初步研究集中在心血管疾病，但随着研究的进展,发现TAMO的作用是多系统的，与神经系统疾病的发展密切相关。肠道是人体内细菌浓度最高的器官,肠道菌群的组成和代谢会影响人体健康。作为连接中枢神经系统和胃肠道的双向通信轴，脑-肠轴为TMAO发挥作用提供了结构基础。本文将对TMA/TMAO与神经系统疾病的相关性进行综述,以期为神经系统疾病的治疗寻找新方向和新靶点。
