We evaluated whether serum folate concentrations were associated with high-risk HPV (hrHPV) infection.
The study population was 11,801 females, aged 18-59 y, enrolled in the National Health and Nutrition Examination Survey (NHANES), from 2003 to 2016, in the United States. In this cross-sectional study, prevalence ratios (PRs) of vaginal hrHPV were calculated using logistic regression models, by quintiles of serum folate.
Females in the lowest quintile had <21.3 nmol/L of folate. Approximately 23% of the females (2733/11,801) were hrHPV positive. In age-adjusted models, folate was significantly associated with hrHPV infection. The PRs and 95% confidence intervals (CIs) were (PR: 1.52; 95% CI: 1.37, 1.70) for the first, (PR: 1.29; 95% CI: 1.15, 1.44) for the second, (PR: 1.19; 95% CI: 1.06, 1.34) for the third, and (PR: 1.09; 95% CI: 0.96, 1.23) for the fourth quintiles, compared with the females in the highest quintile, with a significant P value for trend, <0.0001. The association remained statistically significant after the models were further adjusted for lifestyle and sexual risk factors for hrHPV infection; the females in the lowest quintile were more likely to have hrHPV infection than those in the highest quintile (PR: 1.40; 95% CI: 1.11, 1.53).
Results from this sample of females in the United States suggest that serum folate concentration is inversely associated with hrHPV infection.
目的:我们评估了血清叶酸水平是否与高危型HPV(hrHPV)感染相关。
方法:研究人群为11,801名女性,18-59岁,参加了国家健康和营养检查调查(NHANES),从2003年到2016年,在美国。在这项横断面研究中,使用logistic回归模型计算阴道hrHPV的患病率(PRs),血清叶酸的五分之一。
结果:处于最低五分之一的女性的叶酸含量低于21.3nmol/L。约23%的女性(2,733/11,801),hrHPV阳性。在年龄调整模型中,叶酸与hrHPV感染显著相关。PR和95%置信区间(CI)为(PR:1.52;95%CI:1.37-1.70)(PR:1.29;95%CI:1.15-1.44)第二,(PR:1.19;95%CI:1.06-1.34)第三和(PR:1.09;95%CI:0.96-1.23)第四五分之一,与最高五分之一的女性相比,趋势有显著的p值,<0.0001.在进一步调整hrHPV感染的生活方式和性危险因素后,该关联仍然具有统计学意义;与最高五分之一的女性相比,最低五分之一的女性更可能感染hrHPV(PR:1.40;95%CI:1.11-1.53)。
结论:来自美国女性样本的结果表明,血清叶酸水平与hrHPV感染呈负相关。