OBJECTIVE: This study was conducted to evaluate serum and tissue expression of IL-15 and IL-15Rα in early cases of MF (IA, IB, IIA) at baseline and following phototherapy.
METHODS: Fourteen early MF cases were recruited. Samples were withdrawn prior to starting phototherapy treatment and following near complete clearance of the biopsied lesion or after a maximum of 36 sessions of phototherapy. Samples were assessed for change in expression of IL-15 and IL-15 Rα levels following treatment, whose levels were compared to healthy controls.
RESULTS: Serum and tissue levels of IL-15 and IL-15Rα in early MF cases were significantly higher at baseline than their levels following phototherapy treatment and higher than healthy controls. However, they dropped significantly following treatment with no statistical difference between treated cases and controls, apart from serum IL-15Rα that remained significantly elevated than controls.
CONCLUSIONS: Interleukin-15 and its receptor alpha appear to contribute to the pathogenesis of MF, being significantly elevated than healthy controls, which were normalized following phototherapy treatment, apart from serum IL-15Rα, which remained elevated. Controlling IL-15/IL-15Rα expression is a newly proposed mechanism of action of phototherapy in MF.
目的:本研究旨在评估MF早期患者血清和组织中IL-15和IL-15Rα的表达(IA,IB,IIA)在基线和光疗后。
方法:招募了14例早期MF病例。在开始光疗治疗之前和在活检病变几乎完全清除之后或在最多36次光疗之后取出样品。评估样品在治疗后IL-15和IL-15Rα表达水平的变化。将其水平与健康对照进行比较。
结果:早期MF患者的血清和组织中IL-15和IL-15Rα的水平在基线时明显高于光疗治疗后的水平,并且高于健康对照。然而,它们在治疗后显著下降,治疗病例和对照组之间没有统计学差异,除了血清IL-15Rα仍然显著高于对照组。
结论:白细胞介素-15及其受体α似乎参与了MF的发病机制,显著高于健康对照组,光疗治疗后恢复正常,除了血清IL-15Rα,它仍然升高。控制IL-15/IL-15Rα的表达是最近提出的光疗在MF中的作用机制。