PDF(Pubmed)
Abstract：
Gastric and colorectal cancer are among the most frequently diagnosed malignancies of the gastrointestinal tract. Searching for methods of therapy that complements treatment or has a preventive effect is desirable. Bacterial metabolites safe for human health, which have postbiotic effect, are of interest recently. The study aimed to preliminary assessment of the safety, antimicrobial, and anti-cancer activity of cell-free metabolites of Gluconobacter oxydans strains isolated from Kombucha beverages as an example of the potential postbiotic activity of acetic acid bacteria (AAB). The study material consisted of five AAB strains of Kombucha origin and three human cell lines (gastric adenoma-AGS, colorectal adenoma-HT-29, and healthy cells derived from the endothelium of the human umbilical vein-HUVEC). Results of the study confirms the health safety and functional properties of selected AAB strains, including their potential postbiotic properties. The best potential anticancer activity of the AAB cell-free supernatants was demonstrated against AGS gastric adenoma cells. The conducted research proves the postbiotic potential of selected acetic acid bacteria, especially the KNS30 strain. KEY POINTS: •The beneficial and application properties of acetic acid bacteria are poorly studied. •Gluconobacter oxydans from Kombucha show a postbiotic activity. •The best anticancer activity of the G. oxydans showed against gastric adenoma.
摘要：
胃癌和结直肠癌是最常见的胃肠道恶性肿瘤之一。寻找补充治疗或具有预防作用的治疗方法是期望的。对人体健康安全的细菌代谢物，具有后生物效应，最近有兴趣。该研究旨在对安全性进行初步评估，抗菌，和从康普茶饮料中分离的氧化葡糖杆菌菌株的无细胞代谢物的抗癌活性，作为乙酸细菌（AAB）的潜在后生物活性的例子。研究材料包括五种红茶菌来源的AAB菌株和三种人细胞系（胃腺瘤-AGS，结直肠腺瘤-HT-29，以及来自人脐静脉-HUVEC内皮的健康细胞）。研究结果证实了选定的AAB菌株的健康安全性和功能特性，包括它们潜在的后生物特性。AAB无细胞上清液对AGS胃腺瘤细胞具有最佳的潜在抗癌活性。所进行的研究证明了选定的乙酸细菌的后生物潜力，尤其是KNS30菌株.关键点:•乙酸细菌的有益和应用特性研究甚少。•来自红茶菌的氧化葡糖杆菌显示出一种后生物活性。·氧化银对胃腺瘤的抗癌活性最好。
