Abstract：
BACKGROUND: The term \"chronic prostatitis\" includes many different symptomatic patterns, many aspects of which still remain a mystery. The role of oxidative stress in the pathophysiology of many diseases, including prostatitis, is undisputable.
OBJECTIVE: To evaluate the capabilities of a mineral-vitamin antioxidant complex for the treatment of patients with chronic abacterial prostatitis/chronic pelvic pain syndrome (CP/CPPS).
METHODS: A total of 47 patients with inflammatory type of chronic abacterial prostatitis/chronic pelvic pain syndrome (CPPS) were included in the study. The examination, along with standard tests, included evaluation of the antioxidant status. Patients were randomized into the main group (n=26), and the control group (n=21). All men received standard therapy. However, in the main group, Selzinc-plus was additionally prescribed, 2 tablets per day for 2 months. The results were assessed after 2 months of therapy.
RESULTS: Standard therapy had a significant effect in patients of both groups, which lasted for two months. However, additional antioxidant therapy practically doubled this effect on the symptom scale, although it had no influence on the number of leukocytes in the expressed prostate secretions. At baseline, all patients in both groups had a decrease in antioxidant protection. Two months of taking Selzinc-plus led to normalization of the overall antioxidant status. In the control group, there was also a positive trend in antioxidant status, but significant differences were obtained only in the activity of erythrocyte superoxide dismutase.
CONCLUSIONS: CP/CPPS is accompanied by oxidative stress. Taking Selzinc-plus for two months allows to restore the activity of the antioxidant system.
OBJECTIVE: To evaluate the capabilities of a mineral-vitamin antioxidant complex for the treatment of patients with chronic abacterial prostatitis/chronic pelvic pain syndrome (CP/CPPS).
METHODS: A total of 47 patients with inflammatory type of chronic abacterial prostatitis/chronic pelvic pain syndrome (CPPS) were included in the study. The examination, along with standard tests, included evaluation of the antioxidant status. Patients were randomized into the main group (n=26), and the control group (n=21). All men received standard therapy. However, in the main group, Selzinc-plus was additionally prescribed, 2 tablets per day for 2 months. The results were assessed after 2 months of therapy.
RESULTS: Standard therapy had a significant effect in patients of both groups, which lasted for two months. However, additional antioxidant therapy practically doubled this effect on the symptom scale, although it had no influence on the number of leukocytes in the expressed prostate secretions. At baseline, all patients in both groups had a decrease in antioxidant protection. Two months of taking Selzinc-plus led to normalization of the overall antioxidant status. In the control group, there was also a positive trend in antioxidant status, but significant differences were obtained only in the activity of erythrocyte superoxide dismutase.
CONCLUSIONS: CP/CPPS is accompanied by oxidative stress. Taking Selzinc-plus for two months allows to restore the activity of the antioxidant system.
摘要：
背景：术语“慢性前列腺炎”包括许多不同的症状模式，其中的许多方面仍然是个谜。氧化应激在许多疾病的病理生理学中的作用，包括前列腺炎,是无可争议的。
目的：评估矿物质-维生素抗氧化剂复合物治疗慢性非细菌性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）的能力。
方法：共纳入47例炎症型慢性非细菌性前列腺炎/慢性盆腔疼痛综合征（CPPS）患者。考试,以及标准测试，包括对抗氧化剂状态的评估。患者被随机分为主要组（n=26），对照组(n=21)。所有男性均接受标准治疗。然而,在主要群体中，另外规定了硒锌加，每天2片，持续2个月。治疗2个月后评估结果。
结果：标准治疗对两组患者均有显著疗效，持续了两个月。然而,额外的抗氧化疗法实际上在症状量表上加倍了这种效果，尽管它对表达的前列腺分泌物中的白细胞数量没有影响。在基线,两组患者的抗氧化保护作用均下降.服用Selzinc-plus两个月导致整体抗氧化剂状态正常化。在对照组中，抗氧化状态也有积极的趋势，但是仅在红细胞超氧化物歧化酶的活性上获得了显着差异。
结论：CP/CPPS伴有氧化应激。服用Selzinc-plus两个月可以恢复抗氧化系统的活性。
目的：评估矿物质-维生素抗氧化剂复合物治疗慢性非细菌性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）的能力。
方法：共纳入47例炎症型慢性非细菌性前列腺炎/慢性盆腔疼痛综合征（CPPS）患者。考试,以及标准测试，包括对抗氧化剂状态的评估。患者被随机分为主要组（n=26），对照组(n=21)。所有男性均接受标准治疗。然而,在主要群体中，另外规定了硒锌加，每天2片，持续2个月。治疗2个月后评估结果。
结果：标准治疗对两组患者均有显著疗效，持续了两个月。然而,额外的抗氧化疗法实际上在症状量表上加倍了这种效果，尽管它对表达的前列腺分泌物中的白细胞数量没有影响。在基线,两组患者的抗氧化保护作用均下降.服用Selzinc-plus两个月导致整体抗氧化剂状态正常化。在对照组中，抗氧化状态也有积极的趋势，但是仅在红细胞超氧化物歧化酶的活性上获得了显着差异。
结论：CP/CPPS伴有氧化应激。服用Selzinc-plus两个月可以恢复抗氧化系统的活性。
