Abstract：
Background. Estimated GFR (eGFR) is calculated using serum creatinine (SCr) based equations which have their own limitations. Novel biomarkers like beta trace protein (BTP) are studied for eGFR estimation. The aim of this study is to determine the serum levels of BTP in healthy controls and chronic kidney disease (CKD) cases and to find out the correlation of BTP levels with that of SCr and SCr-based eGFR formulas. Methods. The control group comprised of 20 healthy adults. The cases comprised of 20 patients each in CKD stages 3, 4, and 5, categorized based on eGFR calculated using MDRD formula. Baseline characteristics of the study population were recorded. BTP was measured by ELISA (Enzyme Linked Immunosorbent Assay) method and SCr by modified Jaffe\'s method. The statistical analyses were performed with the SPSS for Windows, version 16.0. Results. The median value of blood urea nitrogen (BUN) in the cases was 26.50 mg/dL (IQR 19.25-37) and for control it was 9.5 mg/dL (IQR 8-12). The median value of SCr in the cases was 2.75 mg/dL (IQR 1.725-4.45) and in the controls, it was 0.7mg/dL (IQR 0.6 -0.8). The median value of BTP in cases was 6389.25 ng/ml (IQR 5610.875-10713.75) and in controls, it was 1089.5 ng/ml (IQR 900.5-1309.75). Conclusion. Serum BTP levels correlated with SCr levels and renal function. We could establish the relationship between the two biomarkers, SCr and BTP, and derive a regression equation.
摘要：
背景。使用基于血清肌酸酐(SCr)的方程计算估计的GFR(eGFR),所述方程具有其自身的局限性。研究了新的生物标志物如β痕量蛋白(BTP)用于eGFR估计。这项研究的目的是确定健康对照和慢性肾脏疾病（CKD）病例中BTP的血清水平，并找出BTP水平与SCr和基于SCr的eGFR公式的相关性。方法。对照组由20名健康成年人组成。这些病例包括20名CKD3、4和5期患者，根据使用MDRD公式计算的eGFR进行分类。记录研究人群的基线特征。酶联免疫吸附试验(ELISA)法测定BTP,改良Jaffe法测定SCr。统计分析使用SPSSforWindows进行，版本16.0。结果。病例中血尿素氮（BUN）的中位数为26.50mg/dL（IQR19.25-37），对照组为9.5mg/dL（IQR8-12）。病例中SCr的中位数为2.75mg/dL（IQR1.725-4.45），对照组为，为0.7mg/dL（IQR0.6-0.8）。病例中BTP的中位数为6389.25ng/ml（IQR5610.875-10713.75），对照组为，它是1089.5ng/ml（IQR900.5-1309.75）。结论。血清BTP水平与SCr水平和肾功能相关。我们可以建立这两种生物标志物之间的关系，SCr和BTP，并推导出回归方程。
