Abstract:
Biofilm formation is an important survival strategy commonly used by bacteria and fungi, which are embedded in a protective extracellular matrix of organic polymers. They are ubiquitous in nature, including humans and other animals, and they can be surface- and non-surface-associated, making them capable of growing in and on many different parts of the body. Biofilms are also complex, forming polymicrobial communities that are difficult to eradicate due to their unique growth dynamics, and clinical infections associated with biofilms are a huge burden in the healthcare setting, as they are often difficult to diagnose and to treat. Our understanding of biofilm formation and development is a fast-paced and important research focus. This review aims to describe the advancements in clinical biofilm research, including both in vitro and in vivo biofilm models, imaging techniques and techniques to analyse the biological functions of the biofilm.
摘要:
生物膜形成是细菌和真菌常用的重要生存策略,嵌入有机聚合物的保护性细胞外基质中。它们在自然界中无处不在,包括人类和其他动物,它们可以是表面和非表面相关的,使它们能够在身体的许多不同部位生长。生物膜也很复杂,形成由于其独特的生长动力学而难以根除的多微生物群落,与生物膜相关的临床感染是医疗保健环境中的巨大负担,因为它们通常难以诊断和治疗。我们对生物膜形成和发展的理解是一个快节奏和重要的研究热点。这篇综述旨在描述临床生物膜研究的进展,包括体外和体内生物膜模型,成像技术和分析生物膜生物学功能的技术。