PDF(Pubmed)
Abstract：
Cryptococcosis, a relatively uncommon infection in cancer patients is often associated with delayed diagnosis and high fatality rate due to its highly heterogeneous and protean manifestations. Early recognition and initiation of appropriate antifungal therapy might have a favourable outcome in such cases. Here we report three cases of Cryptococcosis among cancer patients in a tertiary care cancer centre in South India. All three patients were males of different ages at presentation with immunosuppression in the form of solid organ or hematologic malignancy and were using immunosuppressive medications like steroids or chemotherapeutic agents. They presented with cryptococcemia and cryptococcal meningitis. Patients with microbiologically proven cryptococcosis had poor outcome in this subgroup of patients.
摘要：
隐球菌病,癌症患者中相对罕见的感染通常与诊断延迟和高病死率相关，这是由于其高度异质性和变形蛋白表现。在这种情况下，早期识别和开始适当的抗真菌治疗可能会产生有利的结果。在这里，我们报告了印度南部三级医疗癌症中心的癌症患者中的三例隐球菌病。所有三名患者均为不同年龄的男性，表现为实体器官或血液系统恶性肿瘤形式的免疫抑制，并正在使用免疫抑制药物，例如类固醇或化学治疗剂。他们出现了隐球菌血症和隐球菌性脑膜炎。在该亚组患者中，经微生物证实的隐球菌病患者的预后较差。
