PDF(Pubmed)
Abstract：
Cardiovascular diseases (CVDs) still maintain high morbidity and mortality globally. Helicases, a unique class of enzymes, are extensively implicated in the processes of nucleic acid (NA) metabolism across various organisms. They play a pivotal role in gene expression, inflammatory response, lipid metabolism, and so forth. However, abnormal helicase expression has been associated with immune response, cancer, and intellectual disability in humans. Superfamily II (SFII) is one of the largest and most diverse of the helicase superfamilies. Increasing evidence has implicated SFⅡ helicases in the pathogenesis of multiple CVDs. In this review, we comprehensively review the regulation mechanism of SFⅡ helicases in CVDs including atherosclerosis, myocardial infarction, cardiomyopathies, and heart failure, which will contribute to the investigation of ideal therapeutic targets for CVDs.
摘要：
心血管疾病（CVDs）在全球范围内仍然保持着较高的发病率和死亡率。解旋酶,一类独特的酶，广泛参与各种生物体的核酸（NA）代谢过程。它们在基因表达中起关键作用，炎症反应，脂质代谢，等等。然而,解旋酶的异常表达与免疫反应有关，癌症,人类的智力残疾。超家族II（SFII）是最大，最多样化的解旋酶超家族之一。越来越多的证据表明SFⅡ解旋酶参与了多发性CVDs的发病机制。在这次审查中,本文综述了SFⅡ解旋酶在心血管疾病中的调控机制,包括动脉粥样硬化,心肌梗塞,心肌病,心力衰竭,这将有助于研究心血管疾病的理想治疗靶点。
