PDF(Pubmed)
Abstract：
UNASSIGNED: Uterine fibroids (UFs) are the most common benign tumors in women of reproductive age. The most effective treatment is myomectomy, but there is no long-term or low-invasive treatment option exists. Acupuncture can be used to treat UFs in a variety of ways. However, there is no meta-analytic synthesis including valid data that explored the efficacy of acupuncture for UFs.
UNASSIGNED: To assess the efficacy and safety of acupuncture for treating UFs.
UNASSIGNED: The PRISMA 2020 checklist was used. We identified and extracted the trials through may 2023 from six databases. The quality of the trials was assessed using the risk of bias (2.0). Meta-analysis was performed using RevMan 5.4 software, and it was synthesized using the random-effects model if the included studies were in high heterogeneity. Subgroup and sensitivity analysis were used if necessary.
UNASSIGNED: A total of 1,035 trials were identified, of which 11 were included in the review and meta-analysis. In terms of acupuncture scheme design and fibroid-related symptoms, the trials are highly heterogeneous. All 11 trials have reported acupuncture types, with traditional acupuncture and electroacupuncture being the more representative subgroups. A qualitative review of existing evidence shows that acupuncture has no serious adverse reaction on UFs. Meta-analysis shows that acupuncture can effectively reduce the volume of UFs (MD - 3.89, 95% CI - 5.23 to - 2.56, P < 0.00001) or uterine volume (MD - 16.22, 95% CI - 19.89 To - 12.55, p < 0.00001), reduce the score of fibroid symptoms (MD - 3.03, 95% CI - 3.45 to - 2.60, p < 0.00001), improve the treatment efficiency (RR: 0.19, 95% CI: 0.13 to 0.25, p < 0.00001), and likely do not affect the estrogen level.
UNASSIGNED: To assess the efficacy and safety of acupuncture for treating UFs.
UNASSIGNED: The PRISMA 2020 checklist was used. We identified and extracted the trials through may 2023 from six databases. The quality of the trials was assessed using the risk of bias (2.0). Meta-analysis was performed using RevMan 5.4 software, and it was synthesized using the random-effects model if the included studies were in high heterogeneity. Subgroup and sensitivity analysis were used if necessary.
UNASSIGNED: A total of 1,035 trials were identified, of which 11 were included in the review and meta-analysis. In terms of acupuncture scheme design and fibroid-related symptoms, the trials are highly heterogeneous. All 11 trials have reported acupuncture types, with traditional acupuncture and electroacupuncture being the more representative subgroups. A qualitative review of existing evidence shows that acupuncture has no serious adverse reaction on UFs. Meta-analysis shows that acupuncture can effectively reduce the volume of UFs (MD - 3.89, 95% CI - 5.23 to - 2.56, P < 0.00001) or uterine volume (MD - 16.22, 95% CI - 19.89 To - 12.55, p < 0.00001), reduce the score of fibroid symptoms (MD - 3.03, 95% CI - 3.45 to - 2.60, p < 0.00001), improve the treatment efficiency (RR: 0.19, 95% CI: 0.13 to 0.25, p < 0.00001), and likely do not affect the estrogen level.
摘要：
■子宫肌瘤（UFs）是育龄妇女中最常见的良性肿瘤。最有效的治疗方法是子宫肌瘤切除术,但是没有长期或低侵入性的治疗选择。针灸可用于以多种方式治疗UF。然而,没有包括有效数据的荟萃分析综合，探索针灸治疗UFs的疗效。
■评估针灸治疗UF的疗效和安全性。
■使用了PRISMA2020清单。我们从6个数据库中确定并提取了2023年5月的试验。使用偏倚风险（2.0）评估试验质量。采用RevMan5.4软件进行Meta分析。如果纳入的研究具有高度异质性，则使用随机效应模型进行合成。必要时使用亚组和敏感性分析。
■总共确定了1,035项试验，其中11项纳入综述和荟萃分析.在针灸方案设计和肌瘤相关症状方面，试验是高度异质的。所有11项试验都报道了针灸类型，传统针灸和电针是更具代表性的亚组。对现有证据的定性审查表明，针刺对UFs无严重不良反应。Meta分析显示,针刺可有效降低UFs体积(MD-3.89,95%CI-5.23至-2.56,P<0.00001)或子宫体积(MD-16.22,95%CI-19.89至-12.55,p<0.00001),纤维瘤症状评分降低（MD-3.03，95%CI-3.45至-2.60，p<0.00001），提高治疗效率（RR：0.19，95%CI：0.13至0.25，p<0.00001），并且可能不会影响雌激素水平。
■评估针灸治疗UF的疗效和安全性。
■使用了PRISMA2020清单。我们从6个数据库中确定并提取了2023年5月的试验。使用偏倚风险（2.0）评估试验质量。采用RevMan5.4软件进行Meta分析。如果纳入的研究具有高度异质性，则使用随机效应模型进行合成。必要时使用亚组和敏感性分析。
■总共确定了1,035项试验，其中11项纳入综述和荟萃分析.在针灸方案设计和肌瘤相关症状方面，试验是高度异质的。所有11项试验都报道了针灸类型，传统针灸和电针是更具代表性的亚组。对现有证据的定性审查表明，针刺对UFs无严重不良反应。Meta分析显示,针刺可有效降低UFs体积(MD-3.89,95%CI-5.23至-2.56,P<0.00001)或子宫体积(MD-16.22,95%CI-19.89至-12.55,p<0.00001),纤维瘤症状评分降低（MD-3.03，95%CI-3.45至-2.60，p<0.00001），提高治疗效率（RR：0.19，95%CI：0.13至0.25，p<0.00001），并且可能不会影响雌激素水平。
