PDF(Pubmed)
Abstract：
With population aging rampant globally, Europe faces unique challenges and achievements in chronic disease prevention. Despite this, comprehensive studies examining the diabetes burden remain absent. We investigated the burden of type 1 and type 2 diabetes, alongside high fasting plasma glucose (HFPG), in Europe from 1990-2019, to provide evidence for global diabetes strategies.
Disease burden estimates due to type 1 and type 2 diabetes and HFPG were extracted from the GBD 2019 across Eastern, Central, and Western Europe. We analyzed trends from 1990 to 2019 by Joinpoint regression, examined correlations between diabetes burden and Socio-demographic indices (SDI), healthcare access quality (HAQ), and prevalence using linear regression models. The Population Attributable Fraction (PAF) was used to described diabetes risks.
In Europe, diabetes accounted for 596 age-standardized disability-adjusted life years (DALYs) per 100,000 people in 2019, lower than globally. The disease burden from type 1 and type 2 diabetes was markedly higher in males and escalated with increasing age. Most DALYs were due to type 2 diabetes, showing regional inconsistency, highest in Central Europe. From 1990-2019, age-standardized DALYs attributable to type 2 diabetes rose faster in Eastern and Central Europe, slower in Western Europe. HFPG led to 2794 crude DALYs per 100,000 people in 2019. Type 1 and type 2 diabetes burdens correlated positively with diabetes prevalence and negatively with SDI and HAQ. High BMI (PAF 60.1%) and dietary risks (PAF 34.6%) were significant risk factors.
Europe\'s diabetes burden was lower than the global average, but substantial from type 2 diabetes, reflecting regional heterogeneity. Altered DALYs composition suggested increased YLDs. Addressing the heavy burden of high fasting plasma glucose and the increasing burden of both types diabetes necessitate region-specific interventions to reduce type 2 diabetes risk, improve healthcare systems, and offer cost-effective care.
Disease burden estimates due to type 1 and type 2 diabetes and HFPG were extracted from the GBD 2019 across Eastern, Central, and Western Europe. We analyzed trends from 1990 to 2019 by Joinpoint regression, examined correlations between diabetes burden and Socio-demographic indices (SDI), healthcare access quality (HAQ), and prevalence using linear regression models. The Population Attributable Fraction (PAF) was used to described diabetes risks.
In Europe, diabetes accounted for 596 age-standardized disability-adjusted life years (DALYs) per 100,000 people in 2019, lower than globally. The disease burden from type 1 and type 2 diabetes was markedly higher in males and escalated with increasing age. Most DALYs were due to type 2 diabetes, showing regional inconsistency, highest in Central Europe. From 1990-2019, age-standardized DALYs attributable to type 2 diabetes rose faster in Eastern and Central Europe, slower in Western Europe. HFPG led to 2794 crude DALYs per 100,000 people in 2019. Type 1 and type 2 diabetes burdens correlated positively with diabetes prevalence and negatively with SDI and HAQ. High BMI (PAF 60.1%) and dietary risks (PAF 34.6%) were significant risk factors.
Europe\'s diabetes burden was lower than the global average, but substantial from type 2 diabetes, reflecting regional heterogeneity. Altered DALYs composition suggested increased YLDs. Addressing the heavy burden of high fasting plasma glucose and the increasing burden of both types diabetes necessitate region-specific interventions to reduce type 2 diabetes risk, improve healthcare systems, and offer cost-effective care.
摘要：
■随着全球人口老龄化猖獗，欧洲在慢性病预防方面面临着独特的挑战和成就。尽管如此,研究糖尿病负担的综合研究仍然缺乏。我们调查了1型和2型糖尿病的负担，高空腹血糖（HFPG），在1990-2019年的欧洲，为全球糖尿病策略提供证据。
■由1型和2型糖尿病和HFPG引起的疾病负担估计是从东部地区的GBD2019中提取的，中央,和西欧。我们通过Joinpoint回归分析了1990年至2019年的趋势，检查了糖尿病负担与社会人口指数(SDI)之间的相关性，医疗保健准入质量(HAQ)，和流行率使用线性回归模型。人群归因分数（PAF）用于描述糖尿病风险。
■在欧洲，2019年，糖尿病占每10万人中596个年龄标准化的残疾调整生命年(DALYs)，低于全球。1型和2型糖尿病的疾病负担在男性中显着较高，并且随着年龄的增长而加剧。大多数DALY是由于2型糖尿病，显示区域不一致，在中欧最高。从1990年至2019年，东欧和中欧可归因于2型糖尿病的年龄标准化DALYs上升更快，在西欧更慢。2019年，HFPG导致每10万人中2794个粗DALYs。1型和2型糖尿病负担与糖尿病患病率呈正相关，与SDI和HAQ呈负相关。高BMI(PAF60.1%)和饮食风险(PAF34.6%)是显著的危险因素。
■欧洲的糖尿病负担低于全球平均水平，但很大程度上来自2型糖尿病，反映区域异质性。DALY组成的改变表明YLDs增加。为了解决高空腹血糖的沉重负担和两种类型糖尿病的负担增加，需要针对特定地区的干预措施来降低2型糖尿病的风险。改善医疗保健系统，并提供具有成本效益的护理。
■由1型和2型糖尿病和HFPG引起的疾病负担估计是从东部地区的GBD2019中提取的，中央,和西欧。我们通过Joinpoint回归分析了1990年至2019年的趋势，检查了糖尿病负担与社会人口指数(SDI)之间的相关性，医疗保健准入质量(HAQ)，和流行率使用线性回归模型。人群归因分数（PAF）用于描述糖尿病风险。
■在欧洲，2019年，糖尿病占每10万人中596个年龄标准化的残疾调整生命年(DALYs)，低于全球。1型和2型糖尿病的疾病负担在男性中显着较高，并且随着年龄的增长而加剧。大多数DALY是由于2型糖尿病，显示区域不一致，在中欧最高。从1990年至2019年，东欧和中欧可归因于2型糖尿病的年龄标准化DALYs上升更快，在西欧更慢。2019年，HFPG导致每10万人中2794个粗DALYs。1型和2型糖尿病负担与糖尿病患病率呈正相关，与SDI和HAQ呈负相关。高BMI(PAF60.1%)和饮食风险(PAF34.6%)是显著的危险因素。
■欧洲的糖尿病负担低于全球平均水平，但很大程度上来自2型糖尿病，反映区域异质性。DALY组成的改变表明YLDs增加。为了解决高空腹血糖的沉重负担和两种类型糖尿病的负担增加，需要针对特定地区的干预措施来降低2型糖尿病的风险。改善医疗保健系统，并提供具有成本效益的护理。
