UNASSIGNED: We report the case of a male patient with severe pneumonia-induced respiratory failure. He was abnormally dependent invasive ventilator-assisted ventilation after his condition had improved. Then we found abnormal ventilator waveform and a decline in muscle strength of him. Mitochondrial myopathy was ultimately confirmed by muscle pathological biopsy and body fluid genetic testing. Vitamin B complex, coenzyme Q10, Neprinol AFD, l-arginine, and MITO-TONIC were used to improve mitochondrial function and muscle metabolism. After treatment, discomfort associated with chest tightness, fatigue, cough, and sputum disappeared, and the patient was discharged.
UNASSIGNED: This case presented an uncommon cause of difficult weaning and extubation-acute onset of mitochondrial myopathy. Muscle biopsy and genetic testing of body fluid are essential for diagnosing mitochondrial myopathy. The A3243G mutation in the MT-TL1 gene of mitochondrial DNA contributes to pathogenesis of this case.
■我们报告一例男性重症肺炎引起的呼吸衰竭。病情好转后,他异常依赖有创呼吸机辅助通气。然后我们发现他的呼吸机波形异常和肌肉力量下降。线粒体肌病最终通过肌肉病理活检和体液基因检测得到证实。复合维生素B,辅酶Q10,NeprinolAFD,l-精氨酸,和MITO-TONIC用于改善线粒体功能和肌肉代谢。治疗后,与胸闷相关的不适,疲劳,咳嗽,痰消失了,病人出院了.
■该病例是一个罕见的原因,导致困难的断奶和拔管-线粒体肌病急性发作。肌肉活检和体液基因检测对于诊断线粒体肌病至关重要。线粒体DNA的MT-TL1基因中的A3243G突变有助于该病例的发病。