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Abstract：
OBJECTIVE: Vascular disorders and viral infections are the presumed etiologies of idiopathic sudden sensorineural hearing loss (ISSNHL) and acute sensorineural hearing loss, with no identifiable cause. However, no clinical test for estimating the extent of vascular involvement in ISSNHL has been reported despite its potential impact on prognosis and treatment. We investigated the correlation between the cardio-ankle vascular index (CAVI), which reflects arterial stiffness and elasticity, and hearing improvement to ascertain its usefulness as an additional indicator of ISSNHL prognosis and etiology.
METHODS: We enrolled 182 patients diagnosed with definite ISSNHL. The percentage of mild ISSNHL patients and that of patients experiencing no change were compared between the high-CAVI and low-CAVI groups. Age, initial and final pure-tone average (PTA) values, CAVI, presence or absence of vertigo, and medical histories were retrospectively reviewed and included in univariate and multivariate analyses.
RESULTS: The percentage of mild ISSNHL patients was smaller in the high-CAVI group than in the low-CAVI group, whereas the percentage of patients experiencing no change was smaller in the high-CAVI group than in the low-CAVI group, although patients in the high-CAVI group were significantly older than those in the low-CAVI group. The Cox proportional hazard model revealed that high CAVI, hypertension, younger age, and initial PTA <90 dB were associated with hearing improvement.
CONCLUSIONS: ISSNHL in patients with high CAVI was more severe but had a better prognosis than that in those with low CAVI. CAVI may help evaluate diseases of vascular and other etiologies, as well as ISSNHL.
METHODS: We enrolled 182 patients diagnosed with definite ISSNHL. The percentage of mild ISSNHL patients and that of patients experiencing no change were compared between the high-CAVI and low-CAVI groups. Age, initial and final pure-tone average (PTA) values, CAVI, presence or absence of vertigo, and medical histories were retrospectively reviewed and included in univariate and multivariate analyses.
RESULTS: The percentage of mild ISSNHL patients was smaller in the high-CAVI group than in the low-CAVI group, whereas the percentage of patients experiencing no change was smaller in the high-CAVI group than in the low-CAVI group, although patients in the high-CAVI group were significantly older than those in the low-CAVI group. The Cox proportional hazard model revealed that high CAVI, hypertension, younger age, and initial PTA <90 dB were associated with hearing improvement.
CONCLUSIONS: ISSNHL in patients with high CAVI was more severe but had a better prognosis than that in those with low CAVI. CAVI may help evaluate diseases of vascular and other etiologies, as well as ISSNHL.
摘要：
目的：血管疾病和病毒感染是特发性突发性感觉神经性耳聋（ISSNHL）和急性感觉神经性耳聋的假定病因，没有明确的原因。然而,尽管ISSNHL对预后和治疗有潜在影响,但目前尚无评估ISSNHL血管受累程度的临床试验报告.我们调查了心踝血管指数（CAVI）之间的相关性，反映动脉僵硬度和弹性，和听力改善，以确定其作为ISSNHL预后和病因的额外指标的有效性。
方法：我们招募了182例确诊为明确ISSNHL的患者。在高CAVI和低CAVI组之间比较了轻度ISSNHL患者的百分比和没有变化的患者的百分比。年龄,初始和最终纯音平均(PTA)值，CAVI,是否存在眩晕，和病史进行回顾性分析,并纳入单变量和多变量分析.
结果：高CAVI组轻度ISSNHL患者的百分比小于低CAVI组，而高CAVI组未发生改变的患者百分比小于低CAVI组，尽管高CAVI组患者的年龄明显高于低CAVI组.Cox比例风险模型揭示了高CAVI，高血压,年龄较小,初始PTA<90dB与听力改善有关。
结论：与低CAVI患者相比，高CAVI患者的ISSNHL更严重，但预后更好。CAVI可能有助于评估血管疾病和其他病因，以及ISSNHL。
方法：我们招募了182例确诊为明确ISSNHL的患者。在高CAVI和低CAVI组之间比较了轻度ISSNHL患者的百分比和没有变化的患者的百分比。年龄,初始和最终纯音平均(PTA)值，CAVI,是否存在眩晕，和病史进行回顾性分析,并纳入单变量和多变量分析.
结果：高CAVI组轻度ISSNHL患者的百分比小于低CAVI组，而高CAVI组未发生改变的患者百分比小于低CAVI组，尽管高CAVI组患者的年龄明显高于低CAVI组.Cox比例风险模型揭示了高CAVI，高血压,年龄较小,初始PTA<90dB与听力改善有关。
结论：与低CAVI患者相比，高CAVI患者的ISSNHL更严重，但预后更好。CAVI可能有助于评估血管疾病和其他病因，以及ISSNHL。
