PDF(Pubmed)
Abstract：
UNASSIGNED: Mycobacterium colombiense pneumonia in HIV-infected patients is relatively unusual but is associated with a high mortality rate, as well as high rates of misdiagnosis and delayed diagnosis. Clinical metagenome next-generation sequencing (mNGS) may have potential for its accurate and timely diagnosis.
UNASSIGNED: We retrospectively reviewed the medical records of three HIV-infected patients who presented with M. colombiense pneumonia in Zhejiang Province between January 2019 and December 2020. No specific clinical presentations or radiological manifestations were found in any of the patients. The detection of M. colombiense is 28-55 days earlier using mNGS on bronchoalveolar lavage fluid (BALF) compared to traditional culture methods. A combined treatment of rifabutin, clarithromycin, or azithromycin, and ethambutol did not provide timely relief of symptoms in these three patients. In the early stage of treatment, moxifloxacin and linezolid were used for several weeks. The average course of treatment for all three patients was close to 17 months.
UNASSIGNED: We recommend early BALF mNGS for fast and accurate diagnosis of M. colombiense pneumonia in HIV-infected patients with low CD4 counts and long duration of symptoms. Further, moxifloxacin and linezolid may be beneficial in the early stage of treatment.
UNASSIGNED: We retrospectively reviewed the medical records of three HIV-infected patients who presented with M. colombiense pneumonia in Zhejiang Province between January 2019 and December 2020. No specific clinical presentations or radiological manifestations were found in any of the patients. The detection of M. colombiense is 28-55 days earlier using mNGS on bronchoalveolar lavage fluid (BALF) compared to traditional culture methods. A combined treatment of rifabutin, clarithromycin, or azithromycin, and ethambutol did not provide timely relief of symptoms in these three patients. In the early stage of treatment, moxifloxacin and linezolid were used for several weeks. The average course of treatment for all three patients was close to 17 months.
UNASSIGNED: We recommend early BALF mNGS for fast and accurate diagnosis of M. colombiense pneumonia in HIV-infected patients with low CD4 counts and long duration of symptoms. Further, moxifloxacin and linezolid may be beneficial in the early stage of treatment.
摘要：
■感染艾滋病毒的患者中的哥伦比亚分枝杆菌肺炎相对不常见，但与高死亡率相关，以及高误诊率和延误诊断率。临床宏基因组下一代测序（mNGS）可能具有准确和及时诊断的潜力。
我们回顾性回顾了2019年1月至2020年12月期间浙江省三名感染了结肠支原体肺炎的HIV感染患者的医疗记录。在任何患者中均未发现特定的临床表现或放射学表现。与传统培养方法相比，在支气管肺泡灌洗液（BALF）上使用mNGS检测ColombienseM.利福布汀的联合治疗，克拉霉素,或者阿奇霉素,和乙胺丁醇不能及时缓解这3例患者的症状。在治疗的早期阶段，莫西沙星和利奈唑胺使用数周.所有3例患者的平均疗程接近17个月。
■我们建议早期BALFmNGS，以快速准确地诊断CD4计数低且症状持续时间长的HIV感染患者的结肠支原体肺炎。Further,莫西沙星和利奈唑胺在早期治疗中可能是有益的。
我们回顾性回顾了2019年1月至2020年12月期间浙江省三名感染了结肠支原体肺炎的HIV感染患者的医疗记录。在任何患者中均未发现特定的临床表现或放射学表现。与传统培养方法相比，在支气管肺泡灌洗液（BALF）上使用mNGS检测ColombienseM.利福布汀的联合治疗，克拉霉素,或者阿奇霉素,和乙胺丁醇不能及时缓解这3例患者的症状。在治疗的早期阶段，莫西沙星和利奈唑胺使用数周.所有3例患者的平均疗程接近17个月。
■我们建议早期BALFmNGS，以快速准确地诊断CD4计数低且症状持续时间长的HIV感染患者的结肠支原体肺炎。Further,莫西沙星和利奈唑胺在早期治疗中可能是有益的。
