Abstract：
Stroke is the second leading cause of death worldwide, and hypoxia is a major crisis of the brain after stroke. Therefore, providing oxygen to the brain microenvironment can effectively protect neurons from damage caused by cerebral hypoxia. However, there is a lack of timely and effective means of oxygen delivery clinically to the brain for acute cerebral hypoxia. Here, a phase-change based nano oxygen carrier is reported, which can undergo a phase change in response to increasing temperature in the brain, leading to oxygen release. The nano oxygen carrier demonstrate intracerebral oxygen delivery capacity and is able to release oxygen in the hypoxic and inflammatory region of the brain. In the acute ischemic stroke mouse model, the nano oxygen carrier can effectively reduce the area of cerebral infarction and decrease the level of inflammation triggered by cerebral hypoxia. By taking advantage of the increase in temperature during cerebral hypoxia, phase-change oxygen carrier proposes a new intracerebral oxygen delivery strategy for reducing acute cerebral hypoxia.
摘要：
中风是全球第二大死因,缺氧是中风后大脑的主要危机。因此,为脑微环境提供氧气可以有效保护神经元免受脑缺氧造成的损害。然而,对于急性脑缺氧，临床上缺乏及时有效的脑供氧手段。这里,报道了一种基于相变的纳米氧载体，它可以随着大脑温度的升高而发生相变，导致氧气释放。纳米氧载体显示脑内氧递送能力并且能够在脑的缺氧和炎症区域中释放氧。在急性缺血性中风小鼠模型中,纳米氧载体可有效减少脑梗死面积，降低脑缺氧引发的炎症水平。通过利用脑缺氧期间温度的升高，相变氧载体为减少急性脑缺氧提出了一种新的脑内氧输送策略。
