PDF(Pubmed)
Abstract：
OBJECTIVE: Emerging evidence suggests that there is a close relationship between the human lung and kidney. This study evaluated whether decreased renal function was associated with accelerated pulmonary function decline in a large-scale community-based cohort.
METHODS: A total of 10,028 subjects of the prospective Ansung-Ansan cohort were eligible for the longitudinal analysis of changes in pulmonary function associated with decreased renal function (glomerular filtration rate <60 ml/min/1.73 m2). Logistic regression analysis was performed to evaluate factors associated with decreased baseline renal function, and a linear mixed model compared changes in pulmonary function in participants with and without decreased renal function after propensity score matching (PSM).
RESULTS: At baseline, subjects with and without decreased renal function showed distinct characteristics, and the factors associated with decreased renal function were age, baseline forced vital capacity, hypertension, and white blood cell (WBC) count. A 1:4 PSM of age, sex, body mass index, and smoking status showed that the proportion of those with hypertension and the WBC count differed between the patients with decreased and normal renal function. In the PSM population, those with decreased renal function had a greater decline in forced expiratory volume in the first second (FEV1) than those without (p=0.0402); however, these differences were not found to be evident when hypertension and WBC count were further matched (p=0.0807).
CONCLUSIONS: The results of our study demonstrated that decreased renal function was not directly associated with the rapid decline in pulmonary function in a community-based general population setting.
METHODS: A total of 10,028 subjects of the prospective Ansung-Ansan cohort were eligible for the longitudinal analysis of changes in pulmonary function associated with decreased renal function (glomerular filtration rate <60 ml/min/1.73 m2). Logistic regression analysis was performed to evaluate factors associated with decreased baseline renal function, and a linear mixed model compared changes in pulmonary function in participants with and without decreased renal function after propensity score matching (PSM).
RESULTS: At baseline, subjects with and without decreased renal function showed distinct characteristics, and the factors associated with decreased renal function were age, baseline forced vital capacity, hypertension, and white blood cell (WBC) count. A 1:4 PSM of age, sex, body mass index, and smoking status showed that the proportion of those with hypertension and the WBC count differed between the patients with decreased and normal renal function. In the PSM population, those with decreased renal function had a greater decline in forced expiratory volume in the first second (FEV1) than those without (p=0.0402); however, these differences were not found to be evident when hypertension and WBC count were further matched (p=0.0807).
CONCLUSIONS: The results of our study demonstrated that decreased renal function was not directly associated with the rapid decline in pulmonary function in a community-based general population setting.
摘要：
目的：新的证据表明，人的肺和肾之间有密切的关系。这项研究评估了肾功能下降是否与大规模社区队列中的肺功能加速下降有关。
方法：共有10,028名前瞻性Ansung-Ansan队列受试者符合与肾功能下降相关的肺功能变化的纵向分析（肾小球滤过率<60ml/min/1.73m2）。采用Logistic回归分析评价基线肾功能下降的相关因素,和线性混合模型比较了倾向评分匹配(PSM)后有肾功能下降和无肾功能下降的参与者的肺功能变化.
结果：在基线时，有和没有肾功能下降的受试者表现出明显的特征，与肾功能下降相关的因素是年龄，基线强制肺活量，高血压,和白细胞（WBC）计数。1:4PSM的年龄，性别,身体质量指数,吸烟状况表明，肾功能下降和正常的患者之间，高血压患者的比例和白细胞计数有所不同。在PSM人群中，肾功能下降的患者在第一秒用力呼气量(FEV1)的下降幅度大于无肾功能下降的患者(p=0.0402);然而,当高血压和白细胞计数进一步匹配时,发现这些差异并不明显(p=0.0807).
结论：我们的研究结果表明，在以社区为基础的普通人群中，肾功能下降与肺功能迅速下降没有直接关系。
方法：共有10,028名前瞻性Ansung-Ansan队列受试者符合与肾功能下降相关的肺功能变化的纵向分析（肾小球滤过率<60ml/min/1.73m2）。采用Logistic回归分析评价基线肾功能下降的相关因素,和线性混合模型比较了倾向评分匹配(PSM)后有肾功能下降和无肾功能下降的参与者的肺功能变化.
结果：在基线时，有和没有肾功能下降的受试者表现出明显的特征，与肾功能下降相关的因素是年龄，基线强制肺活量，高血压,和白细胞（WBC）计数。1:4PSM的年龄，性别,身体质量指数,吸烟状况表明，肾功能下降和正常的患者之间，高血压患者的比例和白细胞计数有所不同。在PSM人群中，肾功能下降的患者在第一秒用力呼气量(FEV1)的下降幅度大于无肾功能下降的患者(p=0.0402);然而,当高血压和白细胞计数进一步匹配时,发现这些差异并不明显(p=0.0807).
结论：我们的研究结果表明，在以社区为基础的普通人群中，肾功能下降与肺功能迅速下降没有直接关系。
