关键词: Biliary cyst ductal plate malformation hemoabdomen hepatic cysts lymphocytic cholangitis

来  源:   DOI:10.1177/20551169231216859   PDF(Pubmed)

Abstract:
UNASSIGNED: Ductal plate malformations (DPMs) are poorly documented in the veterinary literature, particularly those of the polycystic liver disease (PCLD) phenotype. A 13-year-old female spayed cat presented with progressive icterus, abdominal distension, weight loss and elevated liver enzymes. Initial empirical treatment consisting of amoxicillin/clavulanate, ursodiol and later prednisolone was attempted; however, clinical signs progressed. On abdominal ultrasound, numerous large hepatic cystic masses were noted, characterized by an anechoic center with a heterogeneous, hyperechoic wall. A post-mortem examination confirmed numerous hepatic cysts, the larger of which resulted in hemorrhage and subsequent hemoabdomen. Histologically, these cysts were determined to be of biliary origin, and a diagnosis of PCLD was assigned.
UNASSIGNED: Herein, we present a detailed report of clinical, gross and histologic findings in a cat clinically affected by PCLD. This case demonstrates that cysts present in this congenital disease can ultimately lead to hepatobiliary malfunction and clinical decline via marked expansion of cysts, compression of the liver and hemoabdomen from cyst rupture. DPMs, specifically PCLD, should be considered in cats presenting with multifocal large hepatic cysts.
摘要:
导管板畸形(DPM)在兽医文献中的记载很少,尤其是多囊肝病(PCLD)表型。一只13岁的母猫出现进行性黄疸,腹胀,体重减轻和肝酶升高。最初的经验性治疗包括阿莫西林/克拉维酸,尝试了熊二醇和后来的泼尼松龙;然而,临床症状进展。在腹部超声检查中,注意到许多大的肝囊性肿块,特征是具有异质的消声中心,高回声墙。验尸证实了许多肝囊肿,其中较大的导致出血和随后的出血。组织学上,这些囊肿被确定为胆道起源,并指定了PCLD的诊断。
这里,我们提供了一份详细的临床报告,临床上受到PCLD影响的猫的大体和组织学发现。该病例表明,这种先天性疾病中存在的囊肿最终可以通过囊肿的明显扩张导致肝胆功能障碍和临床衰退。囊肿破裂对肝脏和血腹部的压迫。DPM,特别是PCLD,在出现多灶性大肝囊肿的猫中应该考虑。
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