Abstract：
Antimicrobial strategies for musculoskeletal infections are typically first developed with in vitro models. The In Vitro Section of the 2023 Orthopedic Research Society Musculoskeletal Infection international consensus meeting (ICM) probed our state of knowledge of in vitro systems with respect to bacteria and biofilm phenotype, standards, in vitro activity, and the ability to predict in vivo efficacy. A subset of ICM delegates performed systematic reviews on 15 questions and made recommendations and assessment of the level of evidence that were then voted on by 72 ICM delegates. Here, we report recommendations and rationale from the reviews and the results of the internet vote. Only two questions received a ≥90% consensus vote, emphasizing the disparate approaches and lack of established consensus for in vitro modeling and interpretation of results. Comments on knowledge gaps and the need for further research on these critical MSKI questions are included.
摘要：
肌肉骨骼感染的抗微生物策略通常首先用体外模型开发。2023年骨科研究学会肌肉骨骼感染（ORSMSKI）国际共识会议（ICM）的体外部分探讨了我们对细菌和生物膜表型的体外系统的了解，标准,体外活性，和预测体内疗效的能力。ICM代表的一部分对15个问题进行了系统的审查，并对证据水平提出了建议和评估，然后由72名ICM代表进行了投票。在这里，我们报告了来自评论和互联网投票结果的建议和理由。只有两个问题获得了超过90％的共识投票，强调不同的方法，缺乏对体外建模和结果解释的共识。包括对知识差距的评论以及对这些关键MSKI问题进行进一步研究的必要性。本文受版权保护。保留所有权利。
