Abstract：
Verruca vulgaris, caused by the human papillomavirus (HPV), can profoundly impact an individual\'s quality of life and necessitate therapeutic intervention. The challenges associated with treating verruca vulgaris are particularly noteworthy when they manifest as the Koebner phenomenon (KP). In this report, we present two cases of verruca vulgaris that developed KP following cryotherapy. Some studies have suggested that pretreatment with laser therapy enhances the efficacy of Photodynamic Therapy (PDT). Given the inefficacy of cryotherapy and the emergence of KP in our patients, we opted for a treatment approach that combined PDT with CO2 fractional laser (CO2FL), resulting in complete resolution without any notable adverse effects or recurrence during the follow-up period. Our cases underscore the importance of considering KP when verruca vulgaris exhibit enlargement and proliferation post-cryotherapy. Furthermore, this combined treatment modality demonstrates its effectiveness and safety. Additionally, our experience highlights the need for a large-scale study to determine the optimal photosensitizer concentration for the treatment of thick, enlarged verruca vulgaris.
摘要：
寻常疣,由人乳头瘤病毒（HPV）引起，可以深刻影响一个人的生活质量，需要治疗干预。当表现为Koebner现象（KP）时，与治疗寻常疣相关的挑战尤其值得注意。在这份报告中,我们介绍了2例冷冻治疗后出现KP的寻常疣。一些研究表明，激光治疗的预处理可以增强光动力疗法（PDT）的功效。鉴于冷冻疗法的无效性和KP在我们的患者中的出现，我们选择了一种将PDT与CO2点阵激光（CO2FL）相结合的治疗方法，导致完全缓解，在随访期间没有任何明显的不良反应或复发。我们的病例强调了当冷冻治疗后寻常疣表现出扩大和增殖时考虑KP的重要性。此外，这种联合治疗方式证明了其有效性和安全性.此外,我们的经验强调需要进行大规模研究，以确定治疗厚，寻常疣扩大。
