PDF(Pubmed)
Abstract：
Chronic obstructive pulmonary disease (COPD) has become one of the most significant chronic diseases in China. According to conventional wisdom, smoking is the pathogenic factor. However, current research indicates that the pathophysiology of COPD may be associated with prior respiratory system events (e.g., childhood hospitalization for pneumonia, chronic bronchitis) and environmental exposure (e.g., dust from workplace, indoor combustion particles). Dyspnea, persistent wheezing, and other respiratory symptoms further point to the need for pulmonary function tests in this population. Reducing the burden of chronic diseases in China requires a thorough understanding of the various factors that influence the occurrence of COPD.
Using a cohort from the natural population, this study used nested case-control analysis. We carried out a number of researches, including questionnaire surveys and pulmonary function testing, in the Northwest and Southeast cohorts of China between 2014 and 2021. After removing any variations in the baseline data between patients and control subjects using propensity score matching analysis, the risk factors were examined using univariate or multivariate regression.
It was discovered that prior history of chronic bronchitis, long-term wheezing symptoms, and environmental exposure-including smoking and biofuel combustion-were risk factors for COPD. Dyspnea, symptoms of mobility limitation, organic matter, and a history of hospitalization for pneumonia at an early age were not significant in the clinical model but their incidence in COPD group is higher than that in healthy population.
COPD screening effectiveness can be increased by looking for individuals with chronic respiratory symptoms. Smokers should give up as soon as they can, and families that have been exposed to biofuels for a long time should convert to clean energy or upgrade their ventilation. Individuals who have previously been diagnosed with emphysema and chronic bronchitis ought to be extra mindful of the prevention or advancement of COPD.
Using a cohort from the natural population, this study used nested case-control analysis. We carried out a number of researches, including questionnaire surveys and pulmonary function testing, in the Northwest and Southeast cohorts of China between 2014 and 2021. After removing any variations in the baseline data between patients and control subjects using propensity score matching analysis, the risk factors were examined using univariate or multivariate regression.
It was discovered that prior history of chronic bronchitis, long-term wheezing symptoms, and environmental exposure-including smoking and biofuel combustion-were risk factors for COPD. Dyspnea, symptoms of mobility limitation, organic matter, and a history of hospitalization for pneumonia at an early age were not significant in the clinical model but their incidence in COPD group is higher than that in healthy population.
COPD screening effectiveness can be increased by looking for individuals with chronic respiratory symptoms. Smokers should give up as soon as they can, and families that have been exposed to biofuels for a long time should convert to clean energy or upgrade their ventilation. Individuals who have previously been diagnosed with emphysema and chronic bronchitis ought to be extra mindful of the prevention or advancement of COPD.
摘要：
■慢性阻塞性肺疾病（COPD）已成为中国最重要的慢性疾病之一。根据传统智慧，吸烟是致病因素。然而,当前的研究表明，COPD的病理生理学可能与先前的呼吸系统事件有关(例如，儿童因肺炎住院，慢性支气管炎)和环境暴露(例如，工作场所的灰尘，室内燃烧颗粒)。呼吸困难,持续的喘息,和其他呼吸道症状进一步表明该人群需要进行肺功能检查.降低我国慢性病负担需要对影响COPD发生的各种因素有深入的了解。
■使用来自自然种群的队列，本研究采用嵌套病例对照分析。我们进行了一些研究，包括问卷调查和肺功能测试，在2014年至2021年之间的中国西北和东南队列中。在使用倾向得分匹配分析去除患者和对照受试者之间的基线数据的任何差异后，采用单因素或多因素回归分析危险因素.
■发现慢性支气管炎的既往史，长期的喘息症状，和环境暴露-包括吸烟和生物燃料燃烧-是COPD的危险因素。呼吸困难,活动受限的症状，有机物,在临床模型中，早期肺炎住院史并不显著，但COPD组的发病率高于健康人群。
■通过寻找有慢性呼吸道症状的个体可以提高COPD筛查的有效性。吸烟者应该尽快放弃，长期接触生物燃料的家庭应该转换为清洁能源或升级通风。先前被诊断患有肺气肿和慢性支气管炎的个体应该特别注意COPD的预防或进展。
■使用来自自然种群的队列，本研究采用嵌套病例对照分析。我们进行了一些研究，包括问卷调查和肺功能测试，在2014年至2021年之间的中国西北和东南队列中。在使用倾向得分匹配分析去除患者和对照受试者之间的基线数据的任何差异后，采用单因素或多因素回归分析危险因素.
■发现慢性支气管炎的既往史，长期的喘息症状，和环境暴露-包括吸烟和生物燃料燃烧-是COPD的危险因素。呼吸困难,活动受限的症状，有机物,在临床模型中，早期肺炎住院史并不显著，但COPD组的发病率高于健康人群。
■通过寻找有慢性呼吸道症状的个体可以提高COPD筛查的有效性。吸烟者应该尽快放弃，长期接触生物燃料的家庭应该转换为清洁能源或升级通风。先前被诊断患有肺气肿和慢性支气管炎的个体应该特别注意COPD的预防或进展。
