PDF(Pubmed)
Abstract：
UNASSIGNED: Helicobacter pylori infection is very common worldwide, and about 10%-16% of these patients develop peptic ulcer disease. However, there is limited research on the impact of H. pylori eradication and peptic ulcer disease treatment sequencing.
UNASSIGNED: We conducted a retrospective study of adult patients diagnosed with H. pylori infection and peptic ulcer disease between October 2020 and April 2021 at our center. Data on primary treatment outcomes, including H. pylori eradication and peptic ulcer disease healing, were collected, and factors that may influence treatment outcomes were analyzed.
UNASSIGNED: A total of 306 patients were included in this study. The sequence of H. pylori eradication and peptic ulcer disease treatment did not significantly affect the outcomes of H. pylori eradication and peptic ulcer disease healing. In addition, patient age, peptic ulcer disease type, clinic type and treatment regimen (including choice of proton pump inhibitor) had no significant impact on H. pylori eradication. However, patient gender and the choice of antibiotic combination proved to be key factors, as eradication rates were lower in female patients compared to males, and the combination of levofloxacin and clarithromycin was the least effective in eradicating H. pylori. Regarding peptic ulcer disease healing, the peptic ulcer disease type was an important influencing factor, since gastric ulcers being more likely to get cured completely compared to duodenal ulcers.
UNASSIGNED: The sequence of H. pylori eradication and peptic ulcer disease treatment does not significantly affect the primary outcomes. Patient gender and the choice of antibiotic combination are important factors in H. pylori eradication, whereas peptic ulcer disease type plays a key role in ulcer healing.
UNASSIGNED: We conducted a retrospective study of adult patients diagnosed with H. pylori infection and peptic ulcer disease between October 2020 and April 2021 at our center. Data on primary treatment outcomes, including H. pylori eradication and peptic ulcer disease healing, were collected, and factors that may influence treatment outcomes were analyzed.
UNASSIGNED: A total of 306 patients were included in this study. The sequence of H. pylori eradication and peptic ulcer disease treatment did not significantly affect the outcomes of H. pylori eradication and peptic ulcer disease healing. In addition, patient age, peptic ulcer disease type, clinic type and treatment regimen (including choice of proton pump inhibitor) had no significant impact on H. pylori eradication. However, patient gender and the choice of antibiotic combination proved to be key factors, as eradication rates were lower in female patients compared to males, and the combination of levofloxacin and clarithromycin was the least effective in eradicating H. pylori. Regarding peptic ulcer disease healing, the peptic ulcer disease type was an important influencing factor, since gastric ulcers being more likely to get cured completely compared to duodenal ulcers.
UNASSIGNED: The sequence of H. pylori eradication and peptic ulcer disease treatment does not significantly affect the primary outcomes. Patient gender and the choice of antibiotic combination are important factors in H. pylori eradication, whereas peptic ulcer disease type plays a key role in ulcer healing.
摘要：
■幽门螺杆菌感染在全球范围内非常普遍，这些患者中约有10％-16％发展为消化性溃疡。然而,关于根除幽门螺杆菌和消化性溃疡疾病治疗测序的影响的研究有限.
我们对2020年10月至2021年4月在我们中心诊断为幽门螺杆菌感染和消化性溃疡的成年患者进行了一项回顾性研究。主要治疗结果的数据，包括根除幽门螺杆菌和治疗消化性溃疡,被收集,并分析了可能影响治疗结局的因素.
■本研究共纳入306例患者。根除H.pylori和消化性溃疡疾病治疗的顺序没有显著影响根除H.pylori和消化性溃疡疾病愈合的结果。此外,患者年龄,消化性溃疡疾病类型，临床类型和治疗方案(包括质子泵抑制剂的选择)对根除幽门螺杆菌无显著影响.然而,患者性别和抗生素组合的选择被证明是关键因素，因为女性患者的根除率低于男性，左氧氟沙星和克拉霉素的组合在根除幽门螺杆菌方面效果最差。关于消化性溃疡疾病的治疗，消化性溃疡的疾病类型是一个重要的影响因素,因为与十二指肠溃疡相比，胃溃疡更容易完全治愈。
■根除幽门螺杆菌和治疗消化性溃疡的顺序对主要结局没有显著影响。患者性别和抗生素组合的选择是根除幽门螺杆菌的重要因素，而消化性溃疡的疾病类型在溃疡愈合中起着关键作用。
我们对2020年10月至2021年4月在我们中心诊断为幽门螺杆菌感染和消化性溃疡的成年患者进行了一项回顾性研究。主要治疗结果的数据，包括根除幽门螺杆菌和治疗消化性溃疡,被收集,并分析了可能影响治疗结局的因素.
■本研究共纳入306例患者。根除H.pylori和消化性溃疡疾病治疗的顺序没有显著影响根除H.pylori和消化性溃疡疾病愈合的结果。此外,患者年龄,消化性溃疡疾病类型，临床类型和治疗方案(包括质子泵抑制剂的选择)对根除幽门螺杆菌无显著影响.然而,患者性别和抗生素组合的选择被证明是关键因素，因为女性患者的根除率低于男性，左氧氟沙星和克拉霉素的组合在根除幽门螺杆菌方面效果最差。关于消化性溃疡疾病的治疗，消化性溃疡的疾病类型是一个重要的影响因素,因为与十二指肠溃疡相比，胃溃疡更容易完全治愈。
■根除幽门螺杆菌和治疗消化性溃疡的顺序对主要结局没有显著影响。患者性别和抗生素组合的选择是根除幽门螺杆菌的重要因素，而消化性溃疡的疾病类型在溃疡愈合中起着关键作用。
