PDF(Pubmed)
Abstract：
UNASSIGNED: In the pathophysiology of Guillain-Barre syndrome (GBS), inflammation and immunity are believed to play a key role. The neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR) have been recently identified as potential markers of inflammation or immunity. This study aimed to investigate whether NLR, MLR, and PLR are associated with GBS characteristics in children. We also assessed the impact of the COVID-19 pandemic on the characteristics of GBS in Iran.
UNASSIGNED: In this retrospective cross-sectional study, we reviewed the records of all 150 children diagnosed with GBS in the Children\'s Medical Center hospital affiliated with Tehran University of Medical Sciences (TUMS) from March 2017 until March 2022. The TUMS research ethics committee approved the study (Ethics code: IR.TUMS.CHMC.REC.1399.125). Patients\' data including gender, age, clinical symptoms, laboratory findings, and electrodiagnostic study results were collected and analyzed.
UNASSIGNED: This study involved 150 children, comprising 93 boys and 57 girls, with an average age of 7.53 ± 3.75 years. The analysis demonstrated that the number of hospitalization days increased with an increase in NLR (p = 0.025). Moreover, patients with abnormal electrodiagnostic study patterns had a higher risk of intensive care unit (ICU) admission (p: 0.027), although according to binary logistic regression, respiratory failure at admission time was the only significant factor increasing the risk of ICU admission (p = 0.035). The study also found that the pandemic has resulted in a shift from acute inflammatory demyelinating polyneuropathy to acute motor axonal neuropathy as the most common EMG-NCV pattern in our patients (p < 0.001).
UNASSIGNED: We found that higher NLR was associated with a longer hospitalization duration and could potentially distinguish between severe and mild cases of GBS. We have also shown that the COVID-19 pandemic has changed our patients\' most frequent electromyography and nerve conduction velocity (EMG-NCV) patterns.
UNASSIGNED: In this retrospective cross-sectional study, we reviewed the records of all 150 children diagnosed with GBS in the Children\'s Medical Center hospital affiliated with Tehran University of Medical Sciences (TUMS) from March 2017 until March 2022. The TUMS research ethics committee approved the study (Ethics code: IR.TUMS.CHMC.REC.1399.125). Patients\' data including gender, age, clinical symptoms, laboratory findings, and electrodiagnostic study results were collected and analyzed.
UNASSIGNED: This study involved 150 children, comprising 93 boys and 57 girls, with an average age of 7.53 ± 3.75 years. The analysis demonstrated that the number of hospitalization days increased with an increase in NLR (p = 0.025). Moreover, patients with abnormal electrodiagnostic study patterns had a higher risk of intensive care unit (ICU) admission (p: 0.027), although according to binary logistic regression, respiratory failure at admission time was the only significant factor increasing the risk of ICU admission (p = 0.035). The study also found that the pandemic has resulted in a shift from acute inflammatory demyelinating polyneuropathy to acute motor axonal neuropathy as the most common EMG-NCV pattern in our patients (p < 0.001).
UNASSIGNED: We found that higher NLR was associated with a longer hospitalization duration and could potentially distinguish between severe and mild cases of GBS. We have also shown that the COVID-19 pandemic has changed our patients\' most frequent electromyography and nerve conduction velocity (EMG-NCV) patterns.
摘要：
■在格林-巴利综合征（GBS）的病理生理学中，炎症和免疫被认为起着关键作用。中性粒细胞-淋巴细胞比率（NLR），单核细胞-淋巴细胞比率（MLR），和血小板-淋巴细胞比率(PLR)最近被认为是炎症或免疫的潜在标志物。本研究旨在调查NLR是否，MLR,PLR与儿童GBS特征相关。我们还评估了COVID-19大流行对伊朗GBS特征的影响。
■在这项回顾性横断面研究中，我们回顾了2017年3月至2022年3月在德黑兰医科大学附属儿童医疗中心医院诊断为GBS的所有150名儿童的记录.TUMS研究伦理委员会批准了这项研究(伦理代码：IR。TUMS。CHMC.REC.1399.125).患者数据，包括性别，年龄,临床症状,实验室发现,收集和分析电诊断研究结果。
■这项研究涉及150名儿童，包括93个男孩和57个女孩，平均年龄为7.53±3.75岁。分析表明，住院天数随着NLR的增加而增加（p=0.025）。此外，电诊断研究模式异常的患者重症监护病房（ICU）入院的风险较高（p：0.027），尽管根据二元逻辑回归，入院时呼吸衰竭是增加ICU入院风险的唯一显著因素(p=0.035).该研究还发现，大流行已导致从急性炎症性脱髓鞘性多发性神经病转变为急性运动性轴索神经病，这是我们患者中最常见的EMG-NCV模式（p<0.001）。
■我们发现，较高的NLR与较长的住院时间有关，并可能区分严重和轻度的GBS病例。我们还表明，COVID-19大流行改变了我们患者最常见的肌电图和神经传导速度（EMG-NCV）模式。
■在这项回顾性横断面研究中，我们回顾了2017年3月至2022年3月在德黑兰医科大学附属儿童医疗中心医院诊断为GBS的所有150名儿童的记录.TUMS研究伦理委员会批准了这项研究(伦理代码：IR。TUMS。CHMC.REC.1399.125).患者数据，包括性别，年龄,临床症状,实验室发现,收集和分析电诊断研究结果。
■这项研究涉及150名儿童，包括93个男孩和57个女孩，平均年龄为7.53±3.75岁。分析表明，住院天数随着NLR的增加而增加（p=0.025）。此外，电诊断研究模式异常的患者重症监护病房（ICU）入院的风险较高（p：0.027），尽管根据二元逻辑回归，入院时呼吸衰竭是增加ICU入院风险的唯一显著因素(p=0.035).该研究还发现，大流行已导致从急性炎症性脱髓鞘性多发性神经病转变为急性运动性轴索神经病，这是我们患者中最常见的EMG-NCV模式（p<0.001）。
■我们发现，较高的NLR与较长的住院时间有关，并可能区分严重和轻度的GBS病例。我们还表明，COVID-19大流行改变了我们患者最常见的肌电图和神经传导速度（EMG-NCV）模式。
