Abstract：
Vocal fold fat injection is a technique for treating glottic insufficiency (GI) resulting from various conditions. The use of fat as a graft has several advantages over other grafts. Similar pliability, and vibratory characteristics as a normal vocal fold, not causing foreign body reactions, having the potential to contain stem cells, and often can be done in the office. Long-term results, however, are unpredictable. The objective of this study is to carry out a systematic review of published articles using the technique of fat injection in the vocal folds.
METHODS: Systematic review.
METHODS: A literature search was conducted utilizing the combination of the following keywords \"vocal folds fat injection,\" \"laryngoplasty,\" and \"autologous fat injection vocal folds.\" The criteria inclusion of the study for the systematic review were based on PICOTS (population, intervention, comparison outcome, timing, and setting) and Preferred Reporting Items for Systematic Reviews and Meta-analyses statements. Outcomes reviewed included technique, study duration, perceptual and acoustic analysis, and quality of life preoperation and 1-year postoperation.
RESULTS: A systematic review on PubMed, Cochrane, and Embase databases included 13 studies analyzing the data of 472 patients, that had fat injection laryngoplasty for treatment of GI. The causes of GI varied substantially across studies. Considerable heterogeneity across studies was found, including technique for harvest, processing the fat, site of injection, and acoustic analysis. In the studies that measured maximum phonation time (MPT) there was a significant improvement in a follow-up of at least 1 year after the injection. The patient\'s perception of vocal quality, measured by the Voice Handicap Index, also showed significant improvement in several studies after fat injection laryngoplasty.
CONCLUSIONS: Fat injection laryngoplasty seems to be safe and effective for GI for at least 12 months. Multiple studies show favorable outcomes, but the lack of control groups, the heterogeneity in inclusion criteria, nonstandardized techniques, and objective voice evaluations limit this evaluation.
METHODS: Systematic review.
METHODS: A literature search was conducted utilizing the combination of the following keywords \"vocal folds fat injection,\" \"laryngoplasty,\" and \"autologous fat injection vocal folds.\" The criteria inclusion of the study for the systematic review were based on PICOTS (population, intervention, comparison outcome, timing, and setting) and Preferred Reporting Items for Systematic Reviews and Meta-analyses statements. Outcomes reviewed included technique, study duration, perceptual and acoustic analysis, and quality of life preoperation and 1-year postoperation.
RESULTS: A systematic review on PubMed, Cochrane, and Embase databases included 13 studies analyzing the data of 472 patients, that had fat injection laryngoplasty for treatment of GI. The causes of GI varied substantially across studies. Considerable heterogeneity across studies was found, including technique for harvest, processing the fat, site of injection, and acoustic analysis. In the studies that measured maximum phonation time (MPT) there was a significant improvement in a follow-up of at least 1 year after the injection. The patient\'s perception of vocal quality, measured by the Voice Handicap Index, also showed significant improvement in several studies after fat injection laryngoplasty.
CONCLUSIONS: Fat injection laryngoplasty seems to be safe and effective for GI for at least 12 months. Multiple studies show favorable outcomes, but the lack of control groups, the heterogeneity in inclusion criteria, nonstandardized techniques, and objective voice evaluations limit this evaluation.
摘要：
声带脂肪注射是用于治疗由各种病症引起的声门功能不全(GI)的技术。使用脂肪作为移植物比其他移植物具有几个优点。类似的柔韧性，和正常声带的振动特性，不会引起异物反应，有可能含有干细胞，经常可以在办公室里做。长期成果,然而,是不可预测的。这项研究的目的是使用在声带中注射脂肪的技术对已发表的文章进行系统的审查。
方法：系统评价。
方法：利用以下关键词“声带脂肪注射，\"\"喉成形术,“和”自体脂肪注射声带。“纳入系统评价研究的标准是基于PICOTS(人群，干预，比较结果，定时,和设置）以及系统评论和荟萃分析声明的首选报告项目。审查的结果包括技术，研究持续时间，感知和声学分析，术前和术后1年的生活质量。
结果：关于PubMed，科克伦,Embase数据库包括13项研究，分析了472名患者的数据，用脂肪注射喉成形术治疗胃肠道。胃肠道的原因在研究中差异很大。在研究中发现了相当大的异质性，包括收获技术，加工脂肪，注射部位,和声学分析。在测量最大发声时间（MPT）的研究中，注射后至少1年的随访显着改善。患者对声音质量的感知，由语音障碍指数衡量，在脂肪注射喉成形术后的几项研究中也显示出显着改善。
结论：脂肪注射喉成形术在至少12个月内似乎是安全有效的。多项研究显示了良好的结果，但是缺乏对照组，纳入标准的异质性，非标准化技术，客观的声音评价限制了这种评价。
方法：系统评价。
方法：利用以下关键词“声带脂肪注射，\"\"喉成形术,“和”自体脂肪注射声带。“纳入系统评价研究的标准是基于PICOTS(人群，干预，比较结果，定时,和设置）以及系统评论和荟萃分析声明的首选报告项目。审查的结果包括技术，研究持续时间，感知和声学分析，术前和术后1年的生活质量。
结果：关于PubMed，科克伦,Embase数据库包括13项研究，分析了472名患者的数据，用脂肪注射喉成形术治疗胃肠道。胃肠道的原因在研究中差异很大。在研究中发现了相当大的异质性，包括收获技术，加工脂肪，注射部位,和声学分析。在测量最大发声时间（MPT）的研究中，注射后至少1年的随访显着改善。患者对声音质量的感知，由语音障碍指数衡量，在脂肪注射喉成形术后的几项研究中也显示出显着改善。
结论：脂肪注射喉成形术在至少12个月内似乎是安全有效的。多项研究显示了良好的结果，但是缺乏对照组，纳入标准的异质性，非标准化技术，客观的声音评价限制了这种评价。
