PDF(Pubmed)
Abstract：
The aim of this study was to assess the effects of guayusa extract and Nordic Lion\'s Mane (LM) on cognition. Using a randomized, double-blind, placebo-controlled, crossover design, we examined the effects of a single dose of 650 mg guayusa extract (AMT: AmaTea® Max) vs. 1 g Nordic-grown Lion\'s Mane (LM) vs. placebo (PL). Participants attended three testing visits consisting of neuropsychological tests (Go/No-go, N-Back, and Serial 7 s tasks) assessing performance, subjective assessments of cognitive perception, and vital signs. Each assessment was measured at baseline (pre-ingestion) and 1 and 2 h post ingestion. AMT significantly (p ≤ 0.05) improved the number of attempts during Serial 7s, total score, number of correct responses, total number of responses, and reaction time during N-Back and improved Go stimulus reaction time, but it reduced the percentage of correct responses in the No-go stimulus response during Go/No-go. LM significantly (p ≤ 0.05) improved the number of attempts during Serial 7s and reaction time during N-Back and improved Go stimulus reaction time in Go/No-go. AMT improved mental clarity, focus, concentration, mood, and productivity at 1 and 2 h (p < 0.05); the ability to tolerate stress at 1 h; and had greater ratings than LM and PL for mental clarity, focus, concentration, and productivity. PL improved focus and concentration at 1 h from baseline (p ≤ 0.05). AMT and LM improved subjective ratings of \"happiness compared to peers\" and \"getting the most out of everything\" (p < 0.05); however, this occurred earlier in LM (i.e., 1 h post ingestion). AMT uniquely elevated blood pressure from baseline. AMT significantly improved cognitive performance and self-perceived cognitive indices of affect over a 2 h period and perceptions of happiness 2 h post ingestion. In comparison, LM helped improve working memory, complex attention, and reaction time 2 h post ingestion and perceptions of happiness over a 2 h period.
摘要：
这项研究的目的是评估瓜柳沙提取物和北欧狮子鬃毛（LM）对认知的影响。使用随机的，双盲,安慰剂对照,交叉设计，我们检查了单剂量650mg瓜柳沙提取物（AMT：AmaTea®Max）与1g北欧生长的狮子鬃毛（LM）与安慰剂（PL）。参与者参加了三次测试访问，包括神经心理学测试(Go/No-go，N-Back,和串行7s任务)评估性能，认知感知的主观评估，和生命体征。在基线(摄入前)和摄入后1和2小时测量每个评估。AMT显着（p≤0.05）提高了串行7s期间的尝试次数，总分,正确回答的数量，回复总数,以及N-Back期间的反应时间和改进的Go刺激反应时间，但它降低了Go/No-go期间No-go刺激响应中正确响应的百分比。LM显着（p≤0.05）改善了连续7s期间的尝试次数和N-Back期间的反应时间，并改善了Go/No-go中的Go刺激反应时间。AMT提高了心理清晰度，焦点,浓度,心情,和生产力在1和2小时（p<0.05）；在1小时耐受压力的能力；并且在心理清晰度方面比LM和PL具有更大的评级，焦点,浓度,和生产力。PL在1小时后改善了病灶和浓度（p≤0.05）。与同龄人相比，AMT和LM提高了“幸福”和“从一切中获得最大收益”的主观评分（p<0.05）；但是，这发生在LM的早期(即，摄入后1小时)。AMT独特地从基线升高血压。AMT显着改善了2小时内的认知表现和自我感知的情感认知指数，以及摄入后2小时的幸福感。相比之下,LM帮助改善工作记忆，复杂的注意力,以及摄入后2小时的反应时间和2小时内对幸福的感知。
