PDF(Pubmed)
Abstract：
We reviewed gastric ulcer healing by dopamine considering several distinctive duodenal key points. Selye and Szabo describe the cysteamine-induced duodenal ulcer in rats as a duodenal stress ulcer in patients. Szabo\'s cysteamine duodenal ulcer as the dopamine duodenal healing and cysteamine as a dopamine antagonist signifies the dopamine agonists anti-ulcer effect and dopamine antagonists ulcerogenic effect. From these viewpoints, we focused on dopamine and gastric ulcer healing. We mentioned antecedent studies on the dopamine presence in the stomach and gastric juice. Then we reviewed, in the timeline, therapy significance arising from the anti-ulcer potency of the various dopamine agonists, which is highly prevailing over the quite persistent beneficial evidence arising from the various dopamine antagonists. Meanwhile, the beneficial effects of several peptides (i.e., amylin, cholecystokinin, leptin, and stable gastric pentadecapeptide BPC 157, suggested as an acting mediator of the dopamine brain-gut axis) were included in the dopamine gastric ulcer story. We attempt to resolve dopamine agonists/antagonists issue with the dopamine significance in the stress (cysteamine as a prototype of the duodenal stress ulcer), and cytoprotection (cysteamine in small dose as a prototype of the cytoprotective agents; cysteamine duodenal ulcer in gastrectomized rats). Thereby, along with dopamine agonists\' beneficial effects, in special circumstances, dopamine antagonists having their own ulcerogenic effect may act as \"mild stress (or)\" or \"small irritant\" counteracting subsequent strong alcohol or stress procedure-induced severe lesions in this particular tissue. Finally, in the conclusion, as a new improvement in further therapy, we emphasized the advantages of the dopamine agents\' application in lower gastrointestinal tract therapy.
摘要：
考虑到几个独特的十二指肠关键点，我们回顾了多巴胺对胃溃疡的愈合。Selye和Szabo将半胱胺诱导的大鼠十二指肠溃疡描述为患者的十二指肠应激性溃疡。Szabo的半胱胺作为多巴胺十二指肠溃疡的愈合和半胱胺作为多巴胺拮抗剂表示多巴胺激动剂的抗溃疡作用和多巴胺拮抗剂的致溃疡作用。从这些观点来看,我们专注于多巴胺和胃溃疡的愈合。我们提到了关于胃和胃液中多巴胺存在的前期研究。然后我们回顾了，在时间线上,各种多巴胺激动剂的抗溃疡效力引起的治疗意义，在各种多巴胺拮抗剂产生的相当持久的有益证据中，这是非常普遍的。同时,几种肽的有益作用(即，胰淀素,胆囊收缩素,瘦素,多巴胺胃溃疡故事中包括了稳定的胃十五肽BPC157，被认为是多巴胺脑-肠轴的作用介质）。我们试图解决多巴胺激动剂/拮抗剂的问题与多巴胺的意义在压力（半胱胺作为十二指肠应激性溃疡的原型），和细胞保护（小剂量半胱胺作为细胞保护剂的原型；胃切除术大鼠的半胱胺十二指肠溃疡）。因此，以及多巴胺激动剂的有益作用，在特殊情况下,具有自身致溃疡作用的多巴胺拮抗剂可起到“轻度应激(或)”或“小刺激物”的作用,抵消随后的强酒精或应激程序在该特定组织中引起的严重损伤。最后,在结论中，作为进一步治疗的新改进，我们强调了多巴胺药物在下胃肠道治疗中的应用优势。
