PDF(Pubmed)
Abstract：
Lysophosphatidic acid (LPA) serves as a fundamental constituent of phospholipids. While prior studies have shown detrimental effects of LPA in a range of pathological conditions, including brain ischemia, no studies have explored the impact of LPA in the context of cardiac arrest (CA). The aim of this study is to evaluate the effects of the intravenous administration of an LPA species containing oleic acid, LPA (18:1) on the neurological function of rats (male, Sprague Dawley) following 8 min of asphyxial CA. Baseline characteristics, including body weight, surgical procedure time, and vital signs before cardiac arrest, were similar between LPA (18:1)-treated (n = 10) and vehicle-treated (n = 10) groups. There was no statistically significant difference in 24 h survival between the two groups. However, LPA (18:1)-treated rats exhibited significantly improved neurological function at 24 h examination (LPA (18:1), 85.4% ± 3.1 vs. vehicle, 74.0% ± 3.3, p = 0.045). This difference was most apparent in the retention of coordination ability in the LPA (18:1) group (LPA (18:1), 71.9% ± 7.4 vs. vehicle, 25.0% ± 9.1, p < 0.001). Overall, LPA (18:1) administration in post-cardiac arrest rats significantly improved neurological function, especially coordination ability at 24 h after cardiac arrest. LPA (18:1) has the potential to serve as a novel therapeutic in cardiac arrest.
摘要：
溶血磷脂酸(LPA)作为磷脂的基本成分。虽然先前的研究已经显示了LPA在一系列病理状况下的有害影响，包括脑缺血,尚无研究探讨LPA在心脏骤停(CA)中的影响.这项研究的目的是评估静脉注射含有油酸的LPA物种的效果，LPA(18:1)对大鼠神经功能的影响(雄性,SpragueDawley）在窒息CA8分钟后。基线特征，包括体重,手术时间，心脏骤停前的生命体征,LPA(18:1)治疗组(n=10)和媒介物治疗组(n=10)之间相似。两组24h生存率差异无统计学意义。然而,LPA(18:1)处理的大鼠在24小时检查时表现出显著改善的神经功能(LPA(18:1),85.4%±3.1vs.车辆,74.0%±3.3，p=0.045）。这种差异在LPA（18：1）组（LPA（18：1），71.9%±7.4vs.车辆,25.0%±9.1，p<0.001)。总的来说,LPA（18：1）在心脏骤停后的大鼠中显著改善神经功能，尤其是心脏骤停后24h的协调能力。LPA(18:1)具有作为心脏骤停的新型治疗方法的潜力。
