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Abstract：
Background and Objectives: In the Western world, back pain and sciatica are among the main causes of disability and absence from work with significant personal, social, and economic costs. This prospective observational study aims to evaluate the effectiveness of a rehabilitation program combined with the administration of Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferol in the treatment of sciatica due to herniated discs in young patients in terms of pain resolution, postural alterations, taking painkillers, and quality of life. Materials and Methods: A prospective observational study was conducted on 128 patients with sciatica. We divided the sample into 3 groups: the Combo group, which received a combination of rehabilitation protocol and daily therapy with 600 mg Alpha Lipoic Acid, 1000 mg Acetyl-L-Carnitine, 50 mg Resveratrol, and 800 UI Cholecalciferol for 30 days; the Reha group, which received only a rehabilitation protocol; and the Supplement group, which received only oral supplementation with 600 mg Alpha Lipoic Acid, 1000 mg Acetyl-L-Carnitine, 50 mg Resveratrol, and 800 UI Cholecalciferol. Clinical assessments were made at the time of recruitment (T0), 30 days after the start of treatment (T1), and 60 days after the end of treatment (T2). The rating scales were as follows: the Numeric Rating Scale (NRS); the Oswestry Disability Questionnaire (ODQ); and the 36-item Short Form Health Survey (SF-36). All patients also underwent an instrumental stabilometric evaluation. Results: At T1, the Combo group showed statistically superior results compared to the other groups for pain (p < 0.05), disability (p < 0.05), and quality of life (p < 0.05). At T2, the Combo group showed statistically superior results compared to the other groups only for pain (p < 0.05) and quality of life (p < 0.05). From the analysis of the stabilometric evaluation data, we only observed a statistically significant improvement at T2 in the Combo group for the average X (p < 0.05) compared to the other groups. Conclusions: The combined treatment of rehabilitation and supplements with anti-inflammatory, pain-relieving, and antioxidant action is effective in the treatment of sciatica and can be useful in improving postural stability.
摘要：
背景和目标：在西方世界，背痛和坐骨神经痛是残疾和缺勤的主要原因，社会,和经济成本。这项前瞻性观察性研究旨在评估康复计划与α硫辛酸的施用相结合的有效性，乙酰-L-肉碱,白藜芦醇,和胆囊钙化醇在疼痛缓解方面治疗年轻患者椎间盘突出引起的坐骨神经痛，姿势改变，服用止痛药，和生活质量。材料与方法：对128例坐骨神经痛患者进行了前瞻性观察研究。我们将样本分为3组：组合组，它接受了康复方案和600毫克α硫辛酸的日常治疗的组合，1000毫克乙酰-L-肉碱，50毫克白藜芦醇，和800UI胆钙化醇持续30天；Reha组，只收到康复方案；和补充小组，仅口服补充600毫克α-硫辛酸，1000毫克乙酰-L-肉碱，50毫克白藜芦醇，和800UI胆固醇。在招募时（T0）进行临床评估，治疗开始后30天（T1），和治疗结束后60天(T2)。评定量表如下：数字评定量表（NRS）；Oswestry残疾问卷（ODQ）；和36项简短形式健康调查（SF-36）。所有患者还接受了仪器稳定性评估。结果：在T1时，Combo组的疼痛效果优于其他组（p<0.05），残疾（p<0.05），和生活质量(p<0.05)。在T2时，Combo组仅在疼痛（p<0.05）和生活质量（p<0.05）方面与其他组相比显示出统计学上优越的结果。通过对稳定性评价数据的分析，与其他组相比，我们仅观察到Combo组平均X在T2时的统计学显着改善（p<0.05）。结论:康复与抗炎的联合治疗,疼痛缓解,和抗氧化作用在治疗坐骨神经痛方面是有效的，并且可以用于改善姿势稳定性。
