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Abstract：
Our understanding of the relationship between oral Candida and systemic conditions has significantly increased recently, which this study aims to extend further by investigating the risks of oral candidiasis. A total of 314 patients were involved in this study and underwent an oral swab test at the Department of Oral Medicine, Hokkaido University Hospital, between January and December 2021. Data were collected on age, sex, white and red blood cell counts, Hb, total protein, vitamin B12, as well as serum albumin, iron, copper, and zinc levels. The clinical fungus samples were swabbed to identify those with Candida species using a MALDI Biotyper, then applied analysis of covariance and multivariant logistic regression analysis. It was possible to assess the oral swab test results without considering the difference between sex (p = 0.946). The oral swab test results were associated with aging (odds ratio: 1.03) and serum albumin levels (odds ratio: 0.32). In summary, the results of our study suggest a relationship between aging and oral candidiasis and offer in-depth insights into how to prevent or treat oral candidiasis onset.
摘要：
我们对口腔念珠菌与全身状况之间的关系的理解最近显着增加，这项研究旨在通过调查口腔念珠菌病的风险来进一步扩展。共有314名患者参与了这项研究，并在口腔内科接受了口腔拭子测试，北海道大学医院,2021年1月至12月。数据收集了年龄，性别,白细胞和红细胞计数，Hb,总蛋白质，维生素B12，以及血清白蛋白，铁,铜，和锌水平。使用MALDIBiotyper对临床真菌样本进行擦拭以鉴定具有念珠菌属的样本，然后应用协方差分析和多变量logistic回归分析。可以在不考虑性别差异的情况下评估口腔拭子测试结果（p=0.946）。口腔拭子测试结果与衰老（比值比：1.03）和血清白蛋白水平（比值比：0.32）相关。总之,我们的研究结果提示了衰老与口腔念珠菌病之间的关系,并对如何预防或治疗口腔念珠菌病的发病提供了深入的见解.
