PDF(Pubmed)
Abstract：
Feline core vaccines strongly recommended for all cats are against Feline panleukopenia virus (FPV), Felid herpesvirus type 1 (FeHV-1), and Feline calicivirus (FCV), but cats can be classified as low- and high-risk based on their lifestyle. The aim of this study was to determine the actual seroprotection against FPV, FeHV-1, and FCV in a large cohort of Italian cats by using the VacciCheck test. A total of 740 cats (567 owned and 173 stray cats; 435 vaccinated and 305 unvaccinated) were analyzed for Protective Antibody Titers (PATs). Differences related to origin, sex, age, breed, FIV/FeLV status, health status, and time elapsed since last vaccination were evaluated. Less than half of the entire cohort (36.4%) had PATs for all three diseases simultaneously, increasing to 48.6% if weak positive values were also considered and 50.3% when considering only the 435 vaccinated cats. Particularly, antibodies were detected against FCV, FPV, and FeHV-1 at protective titers (PATs) in 78.6%, 68.1, and 49.1% of the cats, respectively. In general, owned, neutered, and adult FIV- and/or FeLV-negative cats were the most protected categories, even if not always for the three viruses. Most cats maintained high PATs for 3 years or longer after vaccination against FPV and FCV but not FeHV-1. Long-lasting protective immunity persisted for many years after the last vaccination (more than 18 years in the oldest cats). Nevertheless, since not all cats were protected after so many years and for all pathogens, checking protection via antibody titration could be the best choice to prevent immunity breakdowns. The discussion also focuses on the reliability of antibody titration for the two URTD (upper respiratory tract disease) viruses which, unlike for FPV, is not widely accepted as a valid index of protection.
摘要：
强烈建议所有猫的猫核心疫苗是针对猫泛白细胞减少症病毒（FPV），Felid疱疹病毒1型（FeHV-1），和猫杯状病毒（FCV），但是根据猫的生活方式，猫可以分为低风险和高风险。这项研究的目的是确定针对FPV的实际血清保护，通过使用VacciCheck测试，在一大群意大利猫中的FeHV-1和FCV。分析总共740只猫(567只拥有和173只流浪猫;435只接种疫苗和305只未接种疫苗)的保护性抗体滴度(PAT)。与原产地有关的差异，性别,年龄,品种,FIV/FeLV状态,健康状况,和自上次疫苗接种以来经过的时间进行了评估。整个队列中不到一半（36.4％）同时患有所有三种疾病的PAT，如果还考虑弱正值，则增加到48.6％，仅考虑435只接种疫苗的猫时增加到50.3％。特别是,检测到针对FCV的抗体，FPV,和FeHV-1在保护滴度（PAT）为78.6%，68.1和49.1%的猫，分别。总的来说,拥有,中性，成年FIV和/或FeLV阴性猫是最受保护的类别，即使不总是这三种病毒。大多数猫在接种FPV和FCV后3年或更长时间保持高PAT，但不是FeHV-1。在最后一次疫苗接种后，持久的保护性免疫力持续了很多年（在最古老的猫中超过18年）。然而，因为并不是所有的猫在这么多年后都受到了保护，所有的病原体，通过抗体滴定检查保护可能是防止免疫故障的最佳选择。讨论还重点讨论了两种URTD（上呼吸道疾病）病毒的抗体滴定的可靠性，与FPV不同，没有被广泛接受为有效的保护指标。
