PDF(Pubmed)
Abstract：
Alveolar ridge preservation (ARP) is a well-documented procedure to maintain bone volume after tooth extraction in order to place implants. However, at the end of the healing process, the residual biomaterial that is not reabsorbed remains embedded in the bone over time. Ribose cross-linked biomaterials demonstrated their ability to promote osteoconduction and complete resorption. The aim of this study was to evaluate the histological healing pattern of a novel ribose cross-linked collagen sponge used as a grafting material left exposed in human sockets at the time of tooth extraction. On a single patient, non-restorable lower first molars were extracted on both sides, and a ribose cross-linked collagen sponge was placed bilaterally in the cavities and left uncovered at the end of the surgery. After six months, core biopsies were taken immediately prior to implant placement; after the sample preparation, a histological analysis was performed. The results are very promising for substitution with newly formed bone and the amount of residual material. Ribose cross-linked collagen sponge could represent a valid alternative to conventional biomaterials for ARP procedures with no need for flap advancement and/or the addition of a membrane to cover the graft, reducing the invasiveness, complexity, and costs of the treatment.
摘要：
牙槽脊保留（ARP）是一种有据可查的程序，可在拔牙后保持骨骼体积以放置植入物。然而,在愈合过程结束时，随着时间的推移，未被再吸收的残余生物材料仍然嵌入骨中。核糖交联的生物材料证明了它们促进骨传导和完全吸收的能力。这项研究的目的是评估一种新型核糖交联胶原海绵的组织学愈合模式，该海绵用作拔牙时暴露在人牙槽中的移植材料。在一个病人身上，在两侧拔除不可恢复的下第一磨牙，并将核糖交联的胶原海绵双侧放置在腔中，并在手术结束时露出。六个月后,在植入物放置之前立即进行核心活检；在样品制备后，进行了组织学分析.结果对于用新形成的骨和残余材料的量进行替代非常有希望。核糖交联的胶原蛋白海绵可以代表常规生物材料的有效替代品，用于ARP程序，无需推进皮瓣和/或添加覆盖移植物的膜。减少侵入性，复杂性，和治疗费用。
