PDF(Pubmed)
Abstract：
BACKGROUND: The Italian National Institute of Health (Istituto Superiore di Sanità) funded a 30-month project (July 2021-January 2024) to conduct a twin study of the relationships between Positive Mental Health (PMH) and cellular longevity. Only a few previous studies have focused on the biomarkers of aging in relation to psychological well-being, and none of them exploited the potential of the twin design.
METHODS: In this project, following the standard procedures of the Italian Twin Registry (ITR), we aim to recruit 200 adult twin pairs enrolled in the ITR. They are requested to complete a self-report questionnaire battery on PMH and to undergo a blood withdrawal for the assessment of aging biomarkers, i.e., telomere length and mitochondrial DNA functionality. The association between psychological and aging biomarker measures will be assessed, controlling for genetic and familial confounding effects using the twin study design.
CONCLUSIONS: Biomarker assays are underway. Once data are available for the total study sample, statistical analyses will be performed. The project\'s results may shed light on new mechanisms underlying the mind-body connection and may prove helpful to promote psychological well-being in conjunction with biological functioning.
METHODS: In this project, following the standard procedures of the Italian Twin Registry (ITR), we aim to recruit 200 adult twin pairs enrolled in the ITR. They are requested to complete a self-report questionnaire battery on PMH and to undergo a blood withdrawal for the assessment of aging biomarkers, i.e., telomere length and mitochondrial DNA functionality. The association between psychological and aging biomarker measures will be assessed, controlling for genetic and familial confounding effects using the twin study design.
CONCLUSIONS: Biomarker assays are underway. Once data are available for the total study sample, statistical analyses will be performed. The project\'s results may shed light on new mechanisms underlying the mind-body connection and may prove helpful to promote psychological well-being in conjunction with biological functioning.
摘要：
背景：意大利国家卫生研究所（IstitutoSuperiordiSanità）资助了一个为期30个月的项目（2021年7月至2024年1月），对积极心理健康（PMH）与细胞寿命之间的关系进行了双重研究。以前只有少数研究集中在与心理健康相关的衰老生物标志物上，他们都没有利用孪生设计的潜力。
方法：在这个项目中，遵循意大利双胞胎登记处(ITR)的标准程序，我们的目标是招募200对加入ITR的成年双胞胎。他们被要求完成一份关于PMH的自我报告问卷，并接受抽血以评估衰老的生物标志物，即，端粒长度和线粒体DNA功能。将评估心理和衰老生物标志物之间的关联，使用双胞胎研究设计控制遗传和家族混杂效应。
结论：生物标志物测定正在进行中。一旦总研究样本的数据可用，将进行统计分析。该项目的结果可能会阐明身心联系的新机制，并可能有助于促进心理健康与生物功能的结合。
方法：在这个项目中，遵循意大利双胞胎登记处(ITR)的标准程序，我们的目标是招募200对加入ITR的成年双胞胎。他们被要求完成一份关于PMH的自我报告问卷，并接受抽血以评估衰老的生物标志物，即，端粒长度和线粒体DNA功能。将评估心理和衰老生物标志物之间的关联，使用双胞胎研究设计控制遗传和家族混杂效应。
结论：生物标志物测定正在进行中。一旦总研究样本的数据可用，将进行统计分析。该项目的结果可能会阐明身心联系的新机制，并可能有助于促进心理健康与生物功能的结合。
