PDF(Pubmed)
Abstract：
The most common bacterial isolates in dogs with pyothorax include mixed anaerobes, Enterobacteriaceae (especially Escherichia coli), Pasteurella spp., Streptococcus spp., and Staphylococcus spp. A fluoroquinolone with amoxicillin (±clavulanate) or a fluoroquinolone with clindamycin are the most commonly recommended empirical antimicrobials whilst pending bacterial culture of the pleural effusion. The aim of this study is to review and compare the pleural effusion culture and antimicrobial susceptibility results to the PROTECT ME poster and other published antimicrobial use guidelines. The medical records of 53 dogs diagnosed with pyothorax between 2014 and 2020 at two veterinary referral centres were reviewed. Information, including culture and susceptibility results, was assessed. Antimicrobial susceptibility panels varied; susceptibility to a particular antibiotic was calculated as a percentage of isolates tested against the same antibiotic. A total of 30 of 53 dogs (57.7%) had a positive pleural fluid culture. The most common isolates were Pasteurella species (23.3%), Escherichia coli (23.3%), and mixed anaerobes (20%). From the aerobic isolates, 73-83% were susceptible to a fluoroquinolone, 14/19 (74%) to amoxicillin, and 20/22 (91%) to potentiated amoxicillin. Resistance to clindamycin was documented in 9/13 (69%) aerobic isolates, with all Gram-negative bacteria (9/9) being resistant. The combination of potentiated amoxicillin with marbofloxacin would have been appropriate in most of the dogs (75-92.9%). This study shows a high rate of resistance to clindamycin, which is not a suitable option for monotherapy and may be less effective in combination therapy compared to potentiated amoxicillin.
摘要：
在患有脓胸的狗中最常见的细菌分离株包括混合厌氧菌，肠杆菌科（尤其是大肠杆菌），巴斯德菌属。,链球菌属。,和葡萄球菌属。氟喹诺酮与阿莫西林（±克拉维酸）或氟喹诺酮与克林霉素是最常用的经验性抗菌剂，而胸腔积液的细菌培养。这项研究的目的是回顾和比较胸腔积液培养和抗菌药物敏感性结果与PROTECTME海报和其他已发布的抗菌药物使用指南。回顾了2014年至2020年在两个兽医转诊中心诊断为脓胸的53只狗的医疗记录。信息，包括文化和易感性结果，被评估。抗菌素敏感性小组各不相同；对特定抗生素的敏感性计算为针对相同抗生素测试的分离株的百分比。53只狗中共有30只（57.7％）的胸膜液培养阳性。最常见的分离株是巴氏杆菌（23.3％），大肠杆菌(23.3%)，和混合厌氧菌（20％）。从有氧分离物中，73-83％对氟喹诺酮敏感，14/19（74%）对阿莫西林，和20/22（91％）增强阿莫西林。在9/13（69％）需氧分离株中记录了对克林霉素的抗性，与所有革兰氏阴性细菌（9/9）是耐药。增强的阿莫西林与马波沙星的组合在大多数狗中是合适的（75-92.9％）。这项研究显示对克林霉素的高耐药率，这不是单药治疗的合适选择，与强化阿莫西林相比，联合治疗的效果可能较差。
