Abstract：
Our aims were to obtain the gestational-age-specific median of common logarithmic placental growth factor (PlGF) values in the first trimester in women with a singleton pregnancy in order to generate the gestational-age-specific multiple of the median (MoM) of log10PlGF at 9-13 weeks of gestation, to evaluate screening parameters of MoM of log10PlGF at 9-13 weeks of gestation to predict preterm preeclampsia (PE), and to construct an appropriate prediction model for preterm PE using minimum risk factors in multivariable logistic regression analyses in a retrospective sub-cohort study. Preterm PE occurred in 2.9% (20/700), and PE in 5.1% (36/700). Serum PlGF levels were measured using Elecsys PlGF®. MoMs of log10PlGF at 9-13 weeks of gestation in Japanese women with a singleton pregnancy followed a normal distribution. We determined the appropriate cut-off value of MoM of log10PlGF to predict preterm PE at around a10% false-positive rate (0.854). The MoM of log10PlGF < 0.854 yielded sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio (95% confidence interval [CI]), and negative likelihood ratio (95% CI) of 55.0%, 91.9%, 17.5%, 98.5%, 6.79 (4.22-10.91), and 0.49 (0.30-0.80), respectively. The combination of MoM of log10PlGF and presence of either chronic hypertension or history of PE/gestational hypertension (GH) yielded sensitivity and specificity of 80.0 and 85.7%, respectively, to predict preterm PE. In conclusion, the automated electrochemiluminescence immunoassay for serum PlGF levels in women with singleton pregnancy at 9-13 weeks of gestation may be useful to predict preterm PE.
摘要：
我们的目的是获得单胎妊娠妇女妊娠前三个月的普通对数胎盘生长因子（PlGF）值的胎龄特异性中位数，以便在妊娠9-13周时产生log10PlGF的胎龄特异性中位数（MoM），评估妊娠9-13周时log10PlGF的MoM的筛查参数以预测早产先兆子痫（PE），在一项回顾性亚队列研究中,利用多变量逻辑回归分析中的最小危险因素,构建适当的早产PE预测模型。早产PE发生率为2.9%（20/700），和PE在5.1%（36/700）。使用ElecsysPlGF®测量血清PlGF水平。日本单胎妊娠妇女在妊娠9-13周时log10PlGF的MoMs分布正常。我们确定了log10PlGF的MoM的适当临界值，以预测约10％的假阳性率（0.854）的早产PE。log10PlGF的MoM<0.854产生灵敏度，特异性，正预测值，负预测值，正似然比(95%置信区间[CI])，负似然比（95%CI）为55.0%，91.9%,17.5%,98.5%,6.79(4.22-10.91),和0.49（0.30-0.80），分别。log10PlGF的MoM与慢性高血压或PE/妊娠期高血压（GH）病史的组合产生了80.0和85.7％的敏感性和特异性，分别,预测早产PE。总之,妊娠9~13周单胎妊娠妇女血清PlGF水平的自动化电化学发光免疫测定可能有助于预测早产PE.
