Abstract:
Sarcina ventriculi, also known as Zymosarcina ventriculi and, incorrectly, as Clostridium ventriculi, is rarely encountered in clinical settings. A patient with a complicated gastrointestinal (GI) history, who was acutely presenting with small-bowel obstruction, was found to be colonized by S. ventriculi. The distinctive morphology of this species, with large Gram-variable cocci (up to 3 µm) arranged in two-by-two cuboid clusters reaching up to 20 µm, was key in identifying this bacterium in a stomach biopsy specimen. Sarcina ventriculi appears to be ubiquitously found in nature, and related bacterial species can cause GI-related disease in various animals. Clinical manifestations in humans are broad and often related to other underlying comorbidities. Isolation of S. ventriculi in the laboratory requires anaerobic culture on select media but its absence from standard MALDI-TOF databases complicates identification. Susceptibility data do not exist, so empiric treatment is the only option for this rare pathogen.
摘要:
讽刺室,也被称为ZymosarcinaVentriculi和,不正确,作为心室梭状芽胞杆菌,在临床环境中很少遇到。有复杂胃肠道(GI)病史的患者,他急性出现小肠梗阻,被发现是由脑室沙门氏菌定殖的。这个物种独特的形态,具有大的革兰氏可变球菌(高达3µm),以2×2长方体簇排列,达到20µm,是在胃部活检样本中识别这种细菌的关键。SarcinaVentriculi似乎在自然界中普遍存在,和相关的细菌物种可以在各种动物中引起GI相关疾病。人类的临床表现很广泛,通常与其他潜在的合并症有关。在实验室中分离脑室链球菌需要在选择的培养基上进行厌氧培养,但标准MALDI-TOF数据库中没有这种培养会使鉴定变得复杂。敏感性数据不存在,所以经验性治疗是这种罕见病原体的唯一选择。