Patients were screened for a supportive care trial (NCT04151082). Hypoglossal nerve function was evaluated with genioglossus needle EMG, functional measures with the Iowa oral performance instrument (IOPI), and multi-frequency tissue composition with tongue EIM.
Tongue EIM conductivity was higher for patients with EMG-confirmed cranial nerve XII neuropathy than those without (p = 0.005) and in patients with mild versus normal EMG reinnervation ratings (16 kHz EIM: p = 0.051). Tongue EIM correlated with IOPI strength measurements (e.g., anterior maximum isometric lingual strength: r2 = 0.62, p = 0.020).
Tongue EIM measures related to tongue strength and the presence of XII neuropathy. Noninvasive tongue EIM may be a convenient adjunctive biomarker to assess tongue health in OPC survivors.
方法:筛选患者进行支持治疗试验(NCT04151082)。舌舌下神经功能采用舌舌肌肌电图,用爱荷华州口腔性能仪器(IOPI)进行功能测量,和多频率组织成分与舌EIM。
结果:经EMG证实的颅神经XII神经病患者的舌骨EIM电导率高于无(p=0.005)和轻度与正常EMG神经支配等级(16kHzEIM:p=0.051)的患者。舌头EIM与IOPI强度测量相关(例如,前最大等距舌强度:r2=0.62,p=0.020)。
结论:舌EIM测量与舌强度和XII神经病的存在有关。非侵入性舌头EIM可能是评估OPC幸存者舌头健康的方便的辅助生物标志物。