PDF(Pubmed)
Abstract：
The genetic model system Drosophila has contributed fundamentally to our understanding of mammalian heart specification, development, and congenital heart disease. The relatively simple Drosophila heart is a linear muscular tube that is specified and develops in the embryo and persists throughout the life of the animal. It functions at all stages to circulate hemolymph within the open circulatory system of the body. During Drosophila metamorphosis, the cardiac tube is remodeled, and a new layer of muscle fibers spreads over the ventral surface of the heart to form the ventral longitudinal muscles. The formation of these fibers depends critically upon genes known to be necessary for mammalian second heart field (SHF) formation. Here, we review the prior contributions of the Drosophila system to the understanding of heart development and disease, discuss the importance of the SHF to mammalian heart development and disease, and then discuss how the ventral longitudinal adult cardiac muscles can serve as a novel model for understanding SHF development and disease.
摘要：
遗传模型系统果蝇从根本上促进了我们对哺乳动物心脏规范的理解，发展,先天性心脏病.相对简单的果蝇心脏是一种线性肌肉管，在胚胎中指定并发育，并在动物的整个生命中持续存在。它在所有阶段都起作用，使血淋巴在身体的开放循环系统内循环。在果蝇变态期间，心脏导管被重塑,一层新的肌纤维在心脏的腹侧表面扩散，形成腹侧纵肌。这些纤维的形成关键取决于已知哺乳动物第二心脏场(SHF)形成所必需的基因。这里,我们回顾了果蝇系统对心脏发育和疾病的理解的先前贡献，讨论SHF对哺乳动物心脏发育和疾病的重要性，然后讨论腹侧纵向成人心肌如何作为了解SHF发育和疾病的新模型。
