PDF(Pubmed)
Abstract：
The embryonic development of neural crest cells and subsequent tissue differentiation are intricately regulated by specific transcription factors. Among these, SOX10, a member of the SOX gene family, stands out. Located on chromosome 22q13, the SOX10 gene encodes a transcription factor crucial for the differentiation, migration, and maintenance of tissues derived from neural crest cells. It plays a pivotal role in developing various tissues, including the central and peripheral nervous systems, melanocytes, chondrocytes, and odontoblasts. Mutations in SOX10 have been associated with congenital disorders such as Waardenburg-Shah Syndrome, PCWH syndrome, and Kallman syndrome, underscoring its clinical significance. Furthermore, SOX10 is implicated in neural and neuroectodermal tumors, such as melanoma, malignant peripheral nerve sheath tumors (MPNSTs), and schwannomas, influencing processes like proliferation, migration, and differentiation. In mesenchymal tumors, SOX10 expression serves as a valuable marker for distinguishing between different tumor types. Additionally, SOX10 has been identified in various epithelial neoplasms, including breast, ovarian, salivary gland, nasopharyngeal, and bladder cancers, presenting itself as a potential diagnostic and prognostic marker. However, despite these associations, further research is imperative to elucidate its precise role in these malignancies.
摘要：
神经c细胞的胚胎发育和随后的组织分化受到特定转录因子的复杂调节。其中,SOX10是SOX基因家族的一员,站出来。SOX10基因位于染色体22q13上，编码对分化至关重要的转录因子，迁移,和维持神经c细胞来源的组织。它在发育各种组织中起着关键作用，包括中枢和周围神经系统，黑素细胞,软骨细胞,和成牙本质细胞.SOX10的突变与Waardenburg-Shah综合征等先天性疾病有关，PCWH综合征,和Kallman综合征,强调其临床意义。此外，SOX10与神经和神经外胚层肿瘤有关，比如黑色素瘤，恶性周围神经鞘瘤（MPNSTs），和神经鞘瘤,影响扩散等过程，迁移,和差异化。在间质肿瘤中，SOX10表达作为区分不同肿瘤类型的有价值的标志物。此外,SOX10已在各种上皮肿瘤中被鉴定，包括乳房,卵巢,唾液腺,鼻咽,和膀胱癌，表现为潜在的诊断和预后标志物。然而,尽管有这些联系，进一步的研究对于阐明其在这些恶性肿瘤中的确切作用至关重要.
