PDF(Pubmed)
Abstract：
Efficient drug delivery systems are essential for improving patient outcomes. Acetaminophen (AP), which is a kind of oral administration, is a commonly used pain reliever and fever reducer. However, oral administration carries various health risks, especially overdose and frequent use; for instance, AP is administered approximately 4 times per day. Therefore, the aim of this study is to develop an efficient delivery system for once-daily administration by combining sodium alginate and polysuccinimide (PSI) hydrogels to delay the release of analgesic AP. PSI is a biodegradable polymer that can be used safely and effectively in drug delivery systems because it is eliminated by hydrolysis in the intestine. The use of PSI also improves the mechanical properties of hydrogels and prolongs drug release. In this study, hydrogel characterizations such as mechanical properties, drug dissolution ability, and biodegradability were measured to evaluate the hydrolysis of PSI in the intestine. Based on the results, hydrogels could be designed to improve the structural mechanical properties and to allow the drug to be completely dissolved, and eliminated from the body through PSI hydrolysis in the intestines. In addition, the release profiles of AP in the hydrogels were evaluated, and the hydrogels provided continuous release of AP for 24 h. Our research suggests that sodium alginate/PSI hydrogels can potentially serve as biodegradable delivery systems for AP. These findings may have significant implications for developing efficient drug delivery systems for other classes of drugs.
摘要：
高效的药物递送系统对于改善患者预后至关重要。对乙酰氨基酚（AP），这是一种口服给药，是一种常用的止痛药和退烧剂。然而,口服给药有各种健康风险，特别是过量和频繁使用；例如，AP每天施用约4次。因此,这项研究的目的是通过结合海藻酸钠和聚琥珀酰亚胺（PSI）水凝胶来延迟镇痛AP的释放，开发一种每天一次给药的有效递送系统。PSI是一种可生物降解的聚合物，可以安全有效地用于药物递送系统，因为它在肠道中通过水解被消除。PSI的使用还改善了水凝胶的机械性能并延长了药物释放。在这项研究中,水凝胶表征，如机械性能，药物溶出度，和生物降解性进行了测量，以评估PSI在肠道中的水解。根据结果,水凝胶可以被设计成改善结构机械性能并允许药物完全溶解，并通过肠道中的PSI水解从体内消除。此外,评估了AP在水凝胶中的释放曲线，水凝胶可持续释放AP24小时。我们的研究表明，海藻酸钠/PSI水凝胶可作为AP的生物可降解递送系统。这些发现可能对开发用于其他类别药物的有效药物递送系统具有重要意义。
