PDF(Pubmed)
Abstract：
Chronic kidney disease (CKD) is a significant public health concern. Renal fibrosis is the final common pathway in the progression of kidney diseases, irrespective of the initial injury. Substantial evidence underscores the pivotal role of renal inflammation in the genesis of renal fibrosis. The presence of macrophages within normal renal tissue is significantly increased within diseased renal tissue, indicative of their crucial regulatory function in inflammation and fibrosis. Macrophages manifest a high degree of heterogeneity, exhibiting distinct phenotypic and functional traits in response to diverse stimuli within the local microenvironment in various types of kidney diseases. Broadly, macrophages are categorized into two principal groups: Classically activated, designated as M1 macrophages and alternatively activated, designated as M2 macrophages. A number of experimental models are widely used to study the underlying mechanisms driving renal inflammation and fibrosis progression. The present review delineated the phenotypic and functional attributes of macrophages present in diverse induced models, analyzing their disposition in relation to M1 and M2 polarization states.
摘要：
慢性肾脏病（CKD）是一个重要的公共卫生问题。肾纤维化是肾脏疾病进展的最终共同途径,不管最初的伤害。大量证据强调了肾脏炎症在肾脏纤维化发生中的关键作用。正常肾组织内巨噬细胞的存在在病变肾组织内显著增加,表明它们在炎症和纤维化中的关键调节功能。巨噬细胞表现出高度的异质性，在各种类型的肾脏疾病中，对局部微环境中不同刺激的反应表现出不同的表型和功能特征。广义上,巨噬细胞分为两个主要组：经典激活，被指定为M1巨噬细胞，或者被激活，指定为M2巨噬细胞。许多实验模型被广泛用于研究驱动肾脏炎症和纤维化进展的潜在机制。本综述描述了不同诱导模型中存在的巨噬细胞的表型和功能属性，分析它们与M1和M2偏振态的关系。
