Abstract：
Little is known about the association between sarcopenia and multimorbidity among middle-aged and older adults. This study investigated whether sarcopenia is associated with multimorbidity in middle-aged and older Chinese individuals.
A total of 12,760 participants from China Health and Retirement Longitudinal Study (CHARLS) 2015, with data on 14 specified chronic diseases and sarcopenia status were included in the cross-sectional analysis. A total of 7345 participants without multimorbidity from the CHARLS 2015 were included and followed up in 2018 in the longitudinal analysis. Logistic regression models were used in a cross-sectional investigation to assess the association between sarcopenia status and multimorbidity. In a longitudinal analysis, the relationships between sarcopenia status and multimorbidity were investigated using Cox proportional hazards models.
Multimorbidity was prevalent in the no sarcopenia, possible sarcopenia, and sarcopenia groups at 38.8 % (3765/9713), 56.6 % (1199/2118), and 48.5 % (451/929), respectively. Multivariable regression revealed that both possible sarcopenia (β = 0.088, P<0.001) and sarcopenia (β = 0.028, P = 0.009), contributed to the number of chronic diseases. Logistic regression revealed that possible sarcopenia (OR: 1.56, 95 % CI: 1.39-1.76) was associated with multimorbidity. In the longitudinal analysis, participants in the possible sarcopenia group (HR: 1.19, 95 % CI:1.03-1.38) were more prone to experience new onset multimorbidity than did participants in the no sarcopenia group.
Possible sarcopenia is associated with the development of multimorbidity in middle-aged and older Chinese populations. Health screening of populations with possible sarcopenia can facilitate early detection of multimorbidity.
A total of 12,760 participants from China Health and Retirement Longitudinal Study (CHARLS) 2015, with data on 14 specified chronic diseases and sarcopenia status were included in the cross-sectional analysis. A total of 7345 participants without multimorbidity from the CHARLS 2015 were included and followed up in 2018 in the longitudinal analysis. Logistic regression models were used in a cross-sectional investigation to assess the association between sarcopenia status and multimorbidity. In a longitudinal analysis, the relationships between sarcopenia status and multimorbidity were investigated using Cox proportional hazards models.
Multimorbidity was prevalent in the no sarcopenia, possible sarcopenia, and sarcopenia groups at 38.8 % (3765/9713), 56.6 % (1199/2118), and 48.5 % (451/929), respectively. Multivariable regression revealed that both possible sarcopenia (β = 0.088, P<0.001) and sarcopenia (β = 0.028, P = 0.009), contributed to the number of chronic diseases. Logistic regression revealed that possible sarcopenia (OR: 1.56, 95 % CI: 1.39-1.76) was associated with multimorbidity. In the longitudinal analysis, participants in the possible sarcopenia group (HR: 1.19, 95 % CI:1.03-1.38) were more prone to experience new onset multimorbidity than did participants in the no sarcopenia group.
Possible sarcopenia is associated with the development of multimorbidity in middle-aged and older Chinese populations. Health screening of populations with possible sarcopenia can facilitate early detection of multimorbidity.
摘要：
背景：在中老年人中，关于少肌症与多发病之间的关系知之甚少。这项研究调查了中国中老年人的肌少症是否与多发病有关。
方法：2015年中国健康与退休纵向研究（CHARLS）共12760名参与者，以及14种特定慢性疾病和肌肉减少症的数据纳入横断面分析。在纵向分析中，共有7345名没有CHARLS2015多重性的参与者被纳入并在2018年进行了随访。在横断面调查中使用Logistic回归模型来评估少肌症状态与多重性之间的关联。在纵向分析中，使用Cox比例风险模型研究了肌肉减少症状态与多发病率之间的关系.
结果：多症在无肌少症患者中普遍存在，可能的肌少症,肌少症组为38.8%(3765/9713)，56.6%（1199/2118），和48.5%(451/929)，分别。多因素回归分析显示,肌少症(β=0.088,P<0.001)和肌少症(β=0.028,P=0.009)均有可能。增加了慢性病的数量。Logistic回归分析显示，可能的肌少症（OR：1.56，95％CI：1.39-1.76）与多发病相关。在纵向分析中，与无肌少症组的参与者相比,可能的肌少症组的参与者(HR:1.19,95%CI:1.03~1.38)更容易出现新发多发病.
结论：可能的肌少症与中国中老年人群多发病的发展有关。对可能患有肌少症的人群进行健康筛查可以促进早期发现多发病。
方法：2015年中国健康与退休纵向研究（CHARLS）共12760名参与者，以及14种特定慢性疾病和肌肉减少症的数据纳入横断面分析。在纵向分析中，共有7345名没有CHARLS2015多重性的参与者被纳入并在2018年进行了随访。在横断面调查中使用Logistic回归模型来评估少肌症状态与多重性之间的关联。在纵向分析中，使用Cox比例风险模型研究了肌肉减少症状态与多发病率之间的关系.
结果：多症在无肌少症患者中普遍存在，可能的肌少症,肌少症组为38.8%(3765/9713)，56.6%（1199/2118），和48.5%(451/929)，分别。多因素回归分析显示,肌少症(β=0.088,P<0.001)和肌少症(β=0.028,P=0.009)均有可能。增加了慢性病的数量。Logistic回归分析显示，可能的肌少症（OR：1.56，95％CI：1.39-1.76）与多发病相关。在纵向分析中，与无肌少症组的参与者相比,可能的肌少症组的参与者(HR:1.19,95%CI:1.03~1.38)更容易出现新发多发病.
结论：可能的肌少症与中国中老年人群多发病的发展有关。对可能患有肌少症的人群进行健康筛查可以促进早期发现多发病。
