Abstract：
OBJECTIVE: Left atrial tear (LAT) is a life-threatening complication in dogs with myxomatous mitral valve disease (MMVD). The study objective was to describe clinical presentation, echocardiographic findings, treatment strategies, and survival in dogs with LAT compared to a control group of dogs with a similar stage of MMVD but no LAT.
UNASSIGNED: Two-center retrospective case-controlled study including 15 dogs with and 15 dogs without LAT was conducted. Clinical and echocardiographic data were reviewed, and survival information were collected.
RESULTS: Nine dogs in each group were in stage C of MMVD, while the remaining were in stage B2. No differences between groups were found regarding age, body weight, sex, kidney values, and echocardiography-derived cardiac dimensions. Most reported clinical signs associated with LAT included weakness, respiratory signs, and syncope. Treatment varied and was mainly focused on the management of congestive heart failure. Three dogs with LAT received a pericardiocentesis. All 15 dogs with LAT had died of cardiac causes, five dogs during the first seven days after admission. The median survival time for all 15 dogs with LAT was 52 days compared to 336 days in the control group (P=0.103). When excluding five dogs with LAT that died during the first seven days, the median survival increased to 407 days, not different compared to the control group (P=0.549).
CONCLUSIONS: Dogs with MMVD and LAT have a high short-term mortality; however, when surviving the acute phase, the long-term prognosis may not differ from dogs with a similarly advanced degree of MMVD but without LAT.
UNASSIGNED: Two-center retrospective case-controlled study including 15 dogs with and 15 dogs without LAT was conducted. Clinical and echocardiographic data were reviewed, and survival information were collected.
RESULTS: Nine dogs in each group were in stage C of MMVD, while the remaining were in stage B2. No differences between groups were found regarding age, body weight, sex, kidney values, and echocardiography-derived cardiac dimensions. Most reported clinical signs associated with LAT included weakness, respiratory signs, and syncope. Treatment varied and was mainly focused on the management of congestive heart failure. Three dogs with LAT received a pericardiocentesis. All 15 dogs with LAT had died of cardiac causes, five dogs during the first seven days after admission. The median survival time for all 15 dogs with LAT was 52 days compared to 336 days in the control group (P=0.103). When excluding five dogs with LAT that died during the first seven days, the median survival increased to 407 days, not different compared to the control group (P=0.549).
CONCLUSIONS: Dogs with MMVD and LAT have a high short-term mortality; however, when surviving the acute phase, the long-term prognosis may not differ from dogs with a similarly advanced degree of MMVD but without LAT.
摘要：
目的：左心房撕裂（LAT）是黏液性二尖瓣疾病（MMVD）犬的一种危及生命的并发症。研究目的是描述临床表现，超声心动图检查结果,治疗策略,与具有相似MMVD阶段但没有LAT的狗的对照组相比，具有LAT的狗的存活率。动物和材料和方法：进行了两个中心的回顾性病例对照研究，包括15只带LAT的狗和15只不带LAT的狗。回顾了临床和超声心动图数据，并收集了生存信息。
结果：每组9只狗均处于MMVDC期，其余则处于B2阶段。组间没有发现年龄差异，体重,性别,肾脏价值，和超声心动图衍生的心脏尺寸。大多数报告的与LAT相关的临床体征包括虚弱，呼吸体征,和晕厥。治疗方法多种多样，主要集中在充血性心力衰竭的管理上。三只LAT犬接受了心包穿刺术。所有15只患有LAT的狗都死于心脏病，5只狗在入院后的前7天。所有15只LAT犬的中位生存时间为52天，对照组为336天（P=0.103）。当排除在前7天死亡的5只LAT狗时，中位生存期增加到407天,与对照组相比无差异(P=0.549)。
结论：患有MMVD和LAT的狗具有较高的短期死亡率；然而，当存活到急性期时，与MMVD程度相似但没有LAT的犬相比,长期预后可能没有差异.
结果：每组9只狗均处于MMVDC期，其余则处于B2阶段。组间没有发现年龄差异，体重,性别,肾脏价值，和超声心动图衍生的心脏尺寸。大多数报告的与LAT相关的临床体征包括虚弱，呼吸体征,和晕厥。治疗方法多种多样，主要集中在充血性心力衰竭的管理上。三只LAT犬接受了心包穿刺术。所有15只患有LAT的狗都死于心脏病，5只狗在入院后的前7天。所有15只LAT犬的中位生存时间为52天，对照组为336天（P=0.103）。当排除在前7天死亡的5只LAT狗时，中位生存期增加到407天,与对照组相比无差异(P=0.549)。
结论：患有MMVD和LAT的狗具有较高的短期死亡率；然而，当存活到急性期时，与MMVD程度相似但没有LAT的犬相比,长期预后可能没有差异.
