Abstract：
The present study aimed to inspect the serum levels of the soluble receptors, sTNFR1 and sTNFR2, in patients with COVID-19. The large production of inflammatory cytokines is an essential process in the pathogenesis of COVID-19. TNF is a multifaceted proinflammatory cytokine which has soluble and membrane receptors. Thus, knowing the role of these receptors will help better understand this disease\'s immunopathogenesis. We included 131 patients confirmed for SARS-CoV-2, separated into three groups: ward patients without O2 support, group A (n = 14); ward patients with O2 support, group B (n = 85), and patients in an intensive care unit (ICU), group C (n = 32), making up the receptors dosed by flow cytometry. The results showed that sTNFR1 and sTNFR2 are associated with disease severity, being higher in group C when compared to group A. As for the levels of receptors and their relationship with the degree of lung involvement, we found higher values of sTNFR1 in patients in group 1 (pulmonary involvement < 25%), suggesting that inflammatory processes related to TNF are not necessarily associated with the primary site of infection. When we analysed the patients who passed away compared to those who recovered, both receptors significantly increased the mortality numbers. These findings suggest a relevant influence of soluble receptors in the inflammatory processes involved in the pathogenesis of COVID-19. Wherefore, we suggest using these receptors as biomarkers of severity and mortality of the disease.
摘要：
本研究旨在检查可溶性受体的血清水平，COVID-19患者的sTNFR1和sTNFR2。炎性细胞因子的大量产生是COVID-19发病机理的重要过程。TNF是具有可溶性和膜受体的多方面促炎细胞因子。因此，了解这些受体的作用将有助于更好地理解这种疾病的免疫发病机制。我们纳入了131例确诊为SARS-CoV-2的患者，分为三组：没有O2支持的病房患者，A组(n=14)；O2支持的病房患者，B组（n=85），和重症监护病房(ICU)的病人，C组（n=32），组成通过流式细胞术给药的受体。结果显示sTNFR1和sTNFR2与疾病的严重程度有关,C组比A组高。至于受体水平及其与肺受累程度的关系，我们发现第1组患者的sTNFR1值较高（肺部受累<25%），提示与TNF相关的炎症过程不一定与感染的原发部位相关。当我们分析去世的患者与康复的患者相比时，两种受体均显著增加死亡率.这些发现表明可溶性受体在参与COVID-19发病机制的炎症过程中具有相关影响。因此，我们建议使用这些受体作为疾病严重程度和死亡率的生物标志物.
