Abstract：
Oral submucous fibrosis (OSF) is a chronic, progressive and potentially malignant oral mucosal disease. Patients often have a habit of chewing betel nuts. Areca catechu has been listed as a Class 1 carcinogen by the International Agency for Research on Cancer (IARC), and its main active component, arecoline, is classified as a Group 2B carcinogen by the IARC. The World Health Organization (WHO) categorises OSF as an oral potentially malignant disorder (OPMD). The present guideline describes the risk factors, clinical symptoms and clinical signs of OSF. Clinical staging, auxiliary examination methods, basis for diagnosis and differential diagnosis and the need to improve bad lifestyle habits are proposed and addressed, and local treatment drugs, therapies, dosage and course of treatment, possible adverse reactions, and oral treatment drugs, dosage and course of treatment are proposed. The guideline also addresses the indications for surgical treatment, alternative non-drug treatment methods, selection of treatment plans for different clinical stages, criteria for efficacy evaluation, and preventive measures.
摘要：
口腔粘膜下纤维化(OSF)是一种慢性、进行性和潜在的恶性口腔黏膜疾病。患者经常有嚼槟榔的习惯。槟榔已被国际癌症研究机构（IARC）列为1类致癌物，及其主要活性成分，槟榔林,被IARC列为2B组致癌物。世界卫生组织（WHO）将OSF归类为口腔潜在恶性疾病（OPMD）。本指南描述了风险因素，OSF的临床症状和临床体征。临床分期,辅助检查方法,提出并解决了诊断和鉴别诊断的基础以及改善不良生活习惯的必要性，和当地的治疗药物，疗法,剂量和疗程，可能的不良反应，和口服治疗药物，建议治疗剂量和疗程。该指南还涉及手术治疗的适应症，替代非药物治疗方法，选择不同临床阶段的治疗方案，疗效评价标准，和预防措施。
