PDF(Pubmed)
Abstract：
In 2021, a white-handed gibbon (Hylobates lar) succumbed to illness shortly after transfer from one zoo to another in Germany, due to Francisella tularensis subsp. holarctica infection. To determine the source of infection, whole genome sequencing of the gibbon-derived isolate was performed and wild pest rodents (and captive squirrels) from both zoos were screened for F. tularensis. The F. tularensis whole genome sequence obtained from the gibbon was closely related to previous subclade B.281 sequences obtained from hares from Baden-Wuerttemberg, the same region where the gibbon was first housed. However, F. tularensis DNA was detected in one Norway rat from the receiving zoo. Therefore, neither zoo can be excluded as the source of infection.
摘要：
2021年，一只白手长臂猿（Hylobateslar）在从德国的一个动物园转移到另一个动物园后不久就死于疾病，由于Francisellatularensis亚科。holarctica感染.为了确定感染源，对来自长臂猿的分离株进行了全基因组测序,并对来自两个动物园的野生害虫啮齿动物(和圈养松鼠)进行了土拉伦氏杆菌筛选.从长臂猿获得的F.tularensis全基因组序列与从巴登-符腾堡州的野兔获得的先前亚进化枝B.281序列密切相关，长臂猿最初居住的同一地区。然而,在接收动物园的一只挪威大鼠中检测到F.tularensisDNA。因此,这两个动物园都不能被排除为感染源。
