UNASSIGNED: The study utilized South Korea\'s National Health Insurance Service (NHIS) database, covering 3,505,737 children born between 2007 and 2017 and tracked until 2020. Maternal SLE cases were identified using the World Health Organization\'s International Classification of Diseases Tenth revision (ICD-10) codes and linked with delivery records. Cardiologic disorders were categorized into congenital heart disease (CHD), arrhythmic disorders, and acquired heart disease. Propensity score matching with 1:4 ratios was applied to the set control group.
UNASSIGNED: Among 3,505,737 children, 0.7% (n = 23,330) were born to mothers with SLE. The incidence of preterm birth was significantly higher in the maternal SLE group (5.9% vs. 3.0%). Compared with the control group, children born to mothers with SLE exhibited a significantly elevated risk of overall CHDs (5.5%, adjusted odds ratio [aOR] 1.21; 95% confidence interval [CI] 1.14-1.29), including atrial septal defect (1.18; 1.09-1.28) and patent ductus arteriosus (1.15; 1.03-1.30). In addition, a notably higher risk was observed in arrhythmic disorders (complete atrioventricular block 7.20; 2.41-21.49) and acquired cardiac disorders, including cardiomyopathy (1.40; 1.17-1.68) and mucocutaneous lymph node syndrome (MCLS) (1.27; 1.15-1.43).
UNASSIGNED: Maternal SLE is associated with congenital and acquired cardiac disorders in offspring, including structural, arrhythmic, and MCLS. This study highlights the need for continuous cardiovascular monitoring from the prenatal stage to preadolescence in these children due to multifactorial influences involving maternal autoantibodies, genetic predisposition, and environmental factors.
■该研究利用了韩国的国民健康保险服务(NHIS)数据库,涵盖了2007年至2017年之间出生的3,505,737名儿童,并追踪到2020年。使用世界卫生组织的国际疾病分类第十次修订版(ICD-10)代码确定产妇SLE病例,并与分娩记录相关联。心脏病分为先天性心脏病(CHD),心律失常,和获得性心脏病。将1:4比率匹配的倾向评分应用于设定对照组。
■在3,505,737名儿童中,0.7%(n=23,330)的母亲患有SLE。产妇SLE组早产发生率明显较高(5.9%vs.3.0%)。与对照组相比,SLE母亲所生的孩子患总体CHD的风险显着升高(5.5%,调整后的赔率比[AOR]1.21;95%置信区间[CI]1.14-1.29),包括房间隔缺损(1.18;1.09-1.28)和动脉导管未闭(1.15;1.03-1.30)。此外,在心律失常(完全性房室传导阻滞7.20;2.41-21.49)和获得性心脏病中观察到明显更高的风险,包括心肌病(1.40;1.17-1.68)和粘膜皮肤淋巴结综合征(MCLS)(1.27;1.15-1.43)。
母体SLE与后代的先天性和获得性心脏病有关,包括结构性的,心律失常,和MCLS。这项研究强调,由于涉及母体自身抗体的多因素影响,这些儿童需要从产前阶段到青春期前进行持续的心血管监测。遗传易感性,和环境因素。